About Uromodulin-like 1
Uromodulin-like 1 (UMODL1) is a protein
from Homo sapiens identified by UniProt accession
Q5DID0, 1318 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Uromodulin-like 1 |
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| UniProt accession | Q5DID0 |
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| Gene | UMODL1 |
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| Organism | Homo sapiens |
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| Length | 1318 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (67)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.29
- lymphocyte count · score 0.29
- brain measurement · score 0.28
- neuroblastoma · score 0.26
- lymphocyte percentage of leukocytes · score 0.25
- neurodegenerative disease · score 0.22
- neutrophil percentage of leukocytes · score 0.21
- systolic blood pressure · score 0.21
- inflammatory bowel disease · score 0.12
- thyroid disease · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5DID0-F1 | alphafold | PREDICTED | 69.08 | — |
Amino-acid sequence (1318 residues)
MLRTSGLALL ALVSAVGPSQ ASGFTEKGLS LLGYQLCSHR VTHTVQKVEA VQTSYTSYVS CGGWIPWRRC PKMVYRTQYL VVEVPESRNV TDCCEGYEQL GLYCVLPLNQ SGQFTSRPGA CPAEGPEPST SPCSLDIDCP GLEKCCPWSG GRYCMAPAPQ APERDPVGSW YNVTILVKMD FKELQQVDPR LLNHMRLLHS LVTSALQPMA STVHHLHSAP GNASTTVSRL LLGLPRPLPV ADVSTLLGDI AKRVYEVISV QVQDVNECFY EELNACSGRE LCANLEGSYW CVCHQEAPAT SPRKLNLEWE DCPPVSDYVV LNVTSDSFQV SWRLNSTQNH TFHVRVYRGM ELLRSARTQS QALAVAGLEA GVLYRVKTSY QGCGADVSTT LTIKTNAQVF EVTIKIVNHN LTEKLLNRSS VEYQDFSRQL LHEVESSFPP VVSDLYRSGK LRMQIVSLQA GSVVVRLKLT VQDPGFPMGI STLAPILQPL LASTVFQIDR QGTRVQDWDE CVDSAEHDCS PAAWCINLEG SYTCQCRTTR DATPSRAGRA CEGDLVSPMG GGLSAATGVT VPGLGTGTAA LGLENFTLSP SPGYPQGTPA AGQAWTPEPS PRRGGSNVVG YDRNNTGKGV EQELQGNSIM EPPSWPSPTE DPTGHFLWHA TRSTRETLLN PTWLRNEDSG PSGSVDLPLT STLTALKTPA CVPVSIGRIM VSNVTSTGFH LAWEADLAMD STFQLTLTSM WSPAVVLETW NTSVTLSGLE PGVLHLVEIM AKACGKEGAR AHLKVRTAAR KLIGKVRIKN VRYSESFRNA SSQEYRDFLE LFFRMVRGSL PATMCQHMDA GGVRMEVVSV TNGSIVVEFH LLIIADVDVQ EVSAAFLTAF QTVPLLEVIR GDTFIQDYDE CERKEDDCVP GTSCRNTLGS FTCSCEGGAP DFPVEYSERP CEGDSPGNET WATSPERPLT TAGTKAAFVQ GTSPTPQGLP QRLNLTGAVR VLCEIEKVVV AIQKRFLQQE SIPESSLYLS HPSCNVSHSN GTHVLLEAGW SECGTLMQSN MTNTVVRTTL RNDLSQEGII HHLKILSPIY CAFQNDLLTS SGFTLEWGVY TIIEDLHGAG NFVTEMQLFI GDSPIPQNYS VSASDDVRIE VGLYRQKSNL KVVLTECWAT PSSNARDPIT FSFINNSCPV PNTYTNVIEN GNSNKAQFKL RIFSFINDSI VYLHCKLRVC MESPGATCKI NCNNFRLLQN SETSATHQMS WGPLIRSEGE PPHAEAGLGA GYVVLIVVAI FVLVAGTATL LIVRYQRMNG RYNFKIQSNN FSYQVFYE
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