Immunoglobulin superfamily member 11 (IGSF11)

About Immunoglobulin superfamily member 11

Immunoglobulin superfamily member 11 (IGSF11) is a protein from Homo sapiens identified by UniProt accession Q5DX21, 431 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.

Target properties

Protein name	Immunoglobulin superfamily member 11
UniProt accession	Q5DX21
Gene	IGSF11
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (130)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.41
Abnormality of refraction · score 0.32
intelligence · score 0.31
schizophrenia · score 0.31
age at first sexual intercourse measurement · score 0.25
hip bone mineral density · score 0.25
attention deficit hyperactivity disorder · score 0.25
antisocial behaviour measurement · score 0.24
substance abuse · score 0.24
cystatin C measurement · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5DX21-F1	alphafold	PREDICTED	73.68	—

Amino-acid sequence (431 residues)

MTSQRSPLAP LLLLSLHGVA ASLEVSESPG SIQVARGQPA VLPCTFTTSA ALINLNVIWM VTPLSNANQP EQVILYQGGQ MFDGAPRFHG RVGFTGTMPA TNVSIFINNT QLSDTGTYQC LVNNLPDIGG RNIGVTGLTV LVPPSAPHCQ IQGSQDIGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRNI GLIAGAIGTG AVIIIFCIAL ILGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH TEISSSDNNT LTSSNAYNSR YWSNNPKVHR NTESVSHFSD LGQSFSFHSG NANIPSIYAN GTHLVPGQHK TLVVTANRGS SPQVMSRSNG SVSRKPRPPH THSYTISHAT LERIGAVPVM VPAQSRAGSL V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards