Mesoderm-specific transcript homolog protein (MEST)

About Mesoderm-specific transcript homolog protein

Mesoderm-specific transcript homolog protein (MEST) is a protein from Homo sapiens identified by UniProt accession Q5EB52, 335 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	Mesoderm-specific transcript homolog protein
UniProt accession	Q5EB52
Gene	MEST
Organism	Homo sapiens
Length	335 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

Rare pervasive developmental disorder · score 0.27
cancer · score 0.08
esophageal squamous cell carcinoma · score 0.08
breast cancer · score 0.07
reticulocyte count · score 0.07
BMI-adjusted waist-hip ratio · score 0.05
neoplasm · score 0.05
BMI-adjusted waist circumference · score 0.05
FEV/FVC ratio · score 0.04
placental insufficiency · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5EB52-F1	alphafold	PREDICTED	91.73	—

Amino-acid sequence (335 residues)

MVRRDRLRRM REWWVQVGLL AVPLLAAYLH IPPPQLSPAL HSWKSSGKFF TYKGLRIFYQ DSVGVVGSPE IVVLLHGFPT SSYDWYKIWE GLTLRFHRVI ALDFLGFGFS DKPRPHHYSI FEQASIVEAL LRHLGLQNRR INLLSHDYGD IVAQELLYRY KQNRSGRLTI KSLCLSNGGI FPETHRPLLL QKLLKDGGVL SPILTRLMNF FVFSRGLTPV FGPYTRPSES ELWDMWAGIR NNDGNLVIDS LLQYINQRKK FRRRWVGALA SVTIPIHFIY GPLDPVNPYP EFLELYRKTL PRSTVSILDD HISHYPQLED PMGFLNAYMG FINSF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards