About Zinc finger protein 628
Zinc finger protein 628 (ZNF628) is a protein
from Homo sapiens identified by UniProt accession
Q5EBL2, 1059 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Zinc finger protein 628 |
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| UniProt accession | Q5EBL2 |
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| Gene | ZNF628 |
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| Organism | Homo sapiens |
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| Length | 1059 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- body height · score 0.31
- appendicular lean mass · score 0.30
- lysosomal storage disease · score 0.30
- Alzheimer disease · score 0.30
- multiple sclerosis · score 0.30
- neurodegenerative disease · score 0.30
- Parkinson disease · score 0.30
- forced expiratory volume · score 0.30
- lean body mass · score 0.30
- vital capacity · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5EBL2-F1 | alphafold | PREDICTED | 56.64 | — |
Amino-acid sequence (1059 residues)
MSGVMVGSHA DMAPASTAEG AGEKPGPAAP APAAQYECGE CGKSFRWSSR LLHHQRTHTG ERPYKCPDCP KAFKGSSALL YHQRGHTGER PYQCPDCPKA FKRSSLLQIH RSVHTGLRAF ICGQCGLAFK WSSHYQYHLR QHTGERPYPC PDCPKAFKNS SSLRRHRHVH TGERPYTCGV CGKSFTQSTN LRQHQRVHTG ERPFRCPLCP KTFTHSSNLL LHQRTHGAAP APGTASAAPP PQSREPGKVF VCDAYLQRHL QPHSPPAPPA PPPPPPPVVP ELFLAAAETT VELVYRCDGC EQGFSSEELL LEHQPCPGPD AAPQPQEAPA EAPKADQPPS PLPQPPPPAA APAPGFACLP CGKSFRTVAG LSRHQHSHGA AGGQAFRCGS CDGSFPQLAS LLAHQQCHVE EAAAGRPPPQ AEAAEVTCPQ EPLAPAAPVP PPPPSAPASA ERPYKCAECG KSFKGSSGLR YHLRDHTGER PYQCGECGKA FKRSSLLAIH QRVHTGLRAF TCGQCGLTFK WSSHYQYHLR LHSGERPYAC GECGKAFRNT SCLRRHRHVH TGERPHACGV CGKSFAQTSN LRQHQRVHTG ERPFRCPLCP KTFTHSSNLL LHQRTHSAER PFTCPICGRG FVMAAYLQRH LRTHAPANTP PSTTAPAAGP QPPAPLAAAR APPATQDVHV LPHLQATLSL EVAGGTAQAP SLGPAAPNSQ TFLLVQTAQG LQLIPSSVQP PTPPPPPAPP KLILLPSSSA GAGGGRARQG PRAVGKAGQG AGVVWLPGPG GLGVQGAASA GASGTGQSLI VLQNVGGGEA GPQEMSGVQL QPLRPAPEVT TVQLQPAQEV TTVQLQPAQE VTTVQLQPAQ EVTTVQLQPV AGQLSNSSGG AVATEAPNLL VVQSGAAEEL LTGPGPGEAG DGEASTGVVQ DVLFETLQTD EGLQSVLVLS GADGEQTRLC VQEVETLPPG LTEPPATGPP GQKLLIIRSA PATELLDSSN TGGGTATLQL LAPPPSGPAS GPAGLPGAPA SQMVQVVPAG AGPGVMTPQG LPSIQIVQTL PAVQLVHTF
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