Centromere protein W (CENPW)

About Centromere protein W

Centromere protein W (CENPW) is a protein from Homo sapiens identified by UniProt accession Q5EE01, 88 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.

Target properties

Protein name	Centromere protein W
UniProt accession	Q5EE01
Gene	CENPW
Organism	Homo sapiens
Length	88 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (160)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
lean body mass · score 0.45
body height · score 0.44
cortical surface area measurement · score 0.43
age at menarche · score 0.42
brain volume measurement · score 0.41
type 1 diabetes mellitus · score 0.41
hematocrit · score 0.40
appendicular lean mass · score 0.40
BMI-adjusted hip circumference · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5EE01-F1	alphafold	PREDICTED	89.69	—

Amino-acid sequence (88 residues)

MALSTIVSQR KQIKRKAPRG FLKRVFKRKK PQLRLEKSGD LLVHLNCLLF VHRLAEESRT NACASKCRVI NKEHVLAAAK VILKKSRG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards