Shugoshin 1 (SGO1)

About Shugoshin 1

Shugoshin 1 (SGO1) is a protein from Homo sapiens identified by UniProt accession Q5FBB7, 561 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Shugoshin 1
UniProt accession	Q5FBB7
Gene	SGO1
Organism	Homo sapiens
Length	561 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

chronic atrial and intestinal dysrhythmia · score 0.54
mean corpuscular volume · score 0.38
mathematical ability · score 0.36
body fat percentage · score 0.33
body mass index · score 0.31
lean body mass · score 0.28
mean corpuscular hemoglobin concentration · score 0.28
attention deficit hyperactivity disorder · score 0.27
health study participation · score 0.26
fat body mass · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5FBB7-F1	alphafold	PREDICTED	55.11	—

Amino-acid sequence (561 residues)

MAKERCLKKS FQDSLEDIKK RMKEKRNKNL AEIGKRRSFI AAPCQIITNT STLLKNYQDN NKMLVLALEN EKSKVKEAQD IILQLRKECY YLTCQLYALK GKLTSQQTVE PAQNQEICSS GMDPNSDDSS RNLFVKDLPQ IPLEETELPG QGESFQIEDQ IPTIPQDTLG VDFDSGEAKS TDNVLPRTVS VRSSLKKHCN SICQFDSLDD FETSHLAGKS FEFERVGFLD PLVNMHIPEN VQHNACQWSK DQVNLSPKLI QPGTFTKTKE DILESKSEQT KSKQRDTQER KREEKRKANR RKSKRMSKYK ENKSENKKTV PQKKMHKSVS SNDAYNFNLE EGVHLTPFRQ KVSNDSNREE NNESEVSLCE SSGSGDDSDD LYLPTCKYIQ NPTSNSDRPV TRPLAKRALK YTDEKETEGS KPTKTPTTTP PETQQSPHLS LKDITNVSLY PVVKIRRLSL SPKKNKASPA VALPKRRCTA SVNYKEPTLA SKLRRGDPFT DLCFLNSPIF KQKKDLRRSK KRALEVSPAK EAIFILYYVR EFVSRFPDCR KCKLETHICL R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards