About Long-chain-fatty-acid--CoA ligase ACSBG2
Long-chain-fatty-acid--CoA ligase ACSBG2 (ACSBG2) is a protein
from Homo sapiens identified by UniProt accession
Q5FVE4, 666 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Long-chain-fatty-acid--CoA ligase ACSBG2 |
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| UniProt accession | Q5FVE4 |
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| Gene | ACSBG2 |
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| Organism | Homo sapiens |
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| Length | 666 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.12
- heel bone mineral density · score 0.08
- protein measurement · score 0.05
- platelet component distribution width · score 0.04
- melorheostosis · score 0.04
- Osteoporosis · score 0.04
- osteoporosis · score 0.04
- pyknoachondrogenesis · score 0.03
- autosomal recessive hypophosphatemic rickets · score 0.03
- COVID-19 · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5FVE4-F1 | alphafold | PREDICTED | 90.37 | — |
Amino-acid sequence (666 residues)
MTGTPKTQEG AKDLEVDMNK TEVTPRLWTT CRDGEVLLRL SKHGPGHETP MTIPEFFRES VNRFGTYPAL ASKNGKKWEI LNFNQYYEAC RKAAKSLIKL GLERFHGVGI LGFNSAEWFI TAVGAILAGG LCVGIYATNS AEVCQYVITH AKVNILLVEN DQQLQKILSI PQSSLEPLKA IIQYRLPMKK NNNLYSWDDF MELGRSIPDT QLEQVIESQK ANQCAVLIYT SGTTGIPKGV MLSHDNITWI AGAVTKDFKL TDKHETVVSY LPLSHIAAQM MDIWVPIKIG ALTYFAQADA LKGTLVSTLK EVKPTVFIGV PQIWEKIHEM VKKNSAKSMG LKKKAFVWAR NIGFKVNSKK MLGKYNTPVS YRMAKTLVFS KVKTSLGLDH CHSFISGTAP LNQETAEFFL SLDIPIGELY GLSESSGPHT ISNQNNYRLL SCGKILTGCK NMLFQQNKDG IGEICLWGRH IFMGYLESET ETTEAIDDEG WLHSGDLGQL DGLGFLYVTG HIKEILITAG GENVPPIPVE TLVKKKIPII SNAMLVGDKL KFLSMLLTLK CEMNQMSGEP LDKLNFEAIN FCRGLGSQAS TVTEIVKQQD PLVYKAIQQG INAVNQEAMN NAQRIEKWVI LEKDFSIYGG ELGPMMKLKR HFVAQKYKKQ IDHMYH
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