About Proline-rich transmembrane protein 3
Proline-rich transmembrane protein 3 (PRRT3) is a protein
from Homo sapiens identified by UniProt accession
Q5FWE3, 981 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Proline-rich transmembrane protein 3 |
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| UniProt accession | Q5FWE3 |
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| Gene | PRRT3 |
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| Organism | Homo sapiens |
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| Length | 981 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- body height · score 0.25
- blood protein measurement · score 0.13
- lean body mass · score 0.08
- base metabolic rate measurement · score 0.08
- non-small cell lung carcinoma · score 0.07
- body mass index · score 0.07
- body weight · score 0.07
- appendicular lean mass · score 0.05
- fat body mass · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5FWE3-F1 | alphafold | PREDICTED | 51.93 | — |
Amino-acid sequence (981 residues)
MASSPWGCVC GLLLLLLPLL GTGPALGRGF PRPLENSEIP MIPGAHPKGS VGSEPQAFDV FPENPRADSH RNSDVRHAPA EEMPEKPVAS PLGPALYGPK AAQGAQRERL PVTDDLQMAQ GPSSHGWTGP LDSQELLQQE AVAPHPVGHP HLTFIPTTPR RQLRVATVPP SLQHEGQEGQ WPPRDEGLKA KTKSRVPPTS PSDHQGPPHT LVSHSGTVKR PVLEGQGGFE EHLQEAAQGP HFTQQDPAAP DVGSVPPVEV VYSQEPGAQP DLALARSLPP AEELPVETPK RAGAEVSWEV SSPGPPPKQA DLPDAKDSPG PQPTDPPASE APDRPSKPER AAMNGADPIS PQRVRGAVEA PGTPKSLIPG PSDPGPAVNR TESPMGALQP DEAEEWPGRP QSHPPAPPVQ APSTSRRGLI RVTTQRALGQ PPPPEPTASS MASAPASSPP ANATAPPLRW GPLRRVLSFS WELHVYGVGV LFLLPALLAL AALAAAPAGP RLALVAAVLV LVASALRSAY MLTDPYGSQA RLGVRGGLVL YNLPFPLLLT ALAALTLLGL GAGLPPPLQN PLLLGAVALV HGVGLLATDL LSTWSVLNLL TQGLSCAWGA AVALGTLCLC RRRLLDGPRG WDASPGPRLL AVAGALGLLA SGLQLAAALW LYPGPGRVGR FSWAWWGVHF WLRLLELTWA LALALAAVAA ARPRPPTEHA CWAKLMRLAC PAPSGKSEVP ERPNNCYAGP SNVGAGSLDI SKSLIRNPAE SGQLATPSSG AWGSAASLGR GPQGGPGLSR NGVGPAPSLS ELDLRPPSPI NLSRSIDAAL FREHLVRDSV FQRCGLRGLA SPPPGGALRP RRGSHPKAEL DDAGSSLLRG RCRSLSDVRV RGPVPQHVVE APDGAAAAAS GSSLDSFSRG SLKISWNPWR HGLSSVDSLP LDELPSTVQL LPAPTPAPDS TAARQGDGQG EVQPRGKPGE SRSASSDTIE L
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