F-box only protein 48 (FBXO48)

About F-box only protein 48

F-box only protein 48 (FBXO48) is a protein from Homo sapiens identified by UniProt accession Q5FWF7, 155 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	F-box only protein 48
UniProt accession	Q5FWF7
Gene	FBXO48
Organism	Homo sapiens
Length	155 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.15
Red cell distribution width · score 0.13
leukocyte count · score 0.07
mean platelet volume · score 0.04
Crigler-Najjar syndrome type 2 · score 0.04
transient familial neonatal hyperbilirubinemia · score 0.04
monocyte count · score 0.03
Insulin resistance · score 0.01
Parkinson disease · score 0.01
non-alcoholic steatohepatitis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5FWF7-F1	alphafold	PREDICTED	82.09	—

Amino-acid sequence (155 residues)

MHKNSKRNNN LRVSHTEANS VDAEKEKNES QNNFFELLPA EITFKIFSQL DIRSLCRASL TCRSWNDTIR NSDSLWKPHC MTVRAVCRRE IDDDLESGYS WRVILLRNYQ KSKVKHEWLS GRYSNICSPI SLPEKIMYPM DADTWGEILE AELER

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards