Probable inactive ribonuclease-like protein 12…

About Probable inactive ribonuclease-like protein 12

Probable inactive ribonuclease-like protein 12 (RNASE12) is a protein from Homo sapiens identified by UniProt accession Q5GAN4, 147 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Probable inactive ribonuclease-like protein 12
UniProt accession	Q5GAN4
Gene	RNASE12
Organism	Homo sapiens
Length	147 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

Hepatic veno-occlusive disease - immunodeficiency · score 0.05
Heterotaxia · score 0.04
immunodeficiency 75 · score 0.04
glycoprotein storage disease · score 0.04
idiopathic hypereosinophilic syndrome · score 0.04
autoinflammation with episodic fever and lymphadenopathy · score 0.04
hemoglobin H disease · score 0.04
heterotaxy, visceral, 9, autosomal, with male infertility · score 0.04
Hyperlipoproteinemia type 1 · score 0.04
hemoglobin C-beta-thalassemia syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5GAN4-F1	alphafold	PREDICTED	88.22	—

Amino-acid sequence (147 residues)

MIIMVIIFLV LLFWENEVND EAVMSTLEHL HVDYPQNDVP VPARYCNHMI IQRVIREPDH TCKKEHVFIH ERPRKINGIC ISPKKVACQN LSAIFCFQSE TKFKMTVCQL IEGTRYPACR YHYSPTEGFV LVTCDDLRPD SFLGYVK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Probable inactive ribonuclease-like protein 12 (RNASE12)