About Ankyrin repeat domain-containing protein 36C
Ankyrin repeat domain-containing protein 36C (ANKRD36C) is a protein
from Homo sapiens identified by UniProt accession
Q5JPF3, 1778 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 36C |
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| UniProt accession | Q5JPF3 |
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| Gene | ANKRD36C |
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| Organism | Homo sapiens |
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| Length | 1778 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.27
- monocyte percentage of leukocytes · score 0.21
- eosinophil count · score 0.16
- eosinophil percentage of granulocytes · score 0.15
- diastolic blood pressure · score 0.15
- neutrophil percentage of granulocytes · score 0.12
- migraine disorder · score 0.09
- cortical surface area measurement · score 0.06
- actinic keratosis · score 0.05
- mean platelet volume · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5JPF3-F1 | alphafold | PREDICTED | 51.30 | — |
Amino-acid sequence (1778 residues)
MDDKEPKRWP TLRDRLCSDG FLFPQYPIKP YHLKGIHRAV FYRDLEELKF VLLTRYDINK RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT PLIKAVQLRQ EACATLLLQN GADPNITDVF GRTALHYAVY NEDTSMIEKL LSYGANIEEC SEDEYPPLFL AVSQRKVKMV EFLLKKKANI NAVDYLGRSA LIHAVTLGEK DIVILLLQHN IDVFSRDVYG KLAEDYASEA KNRVIFELIY EYERKKHEEL SINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT VSSQKQPALK GTSDKNDSVS NTATEIKDEQ KSGTVSSQKQ PALKDTSDKN DSVSNTATEI KDEQKSGTVL PAVEQCLNRS LYRPDAVAQP VTEDEFALES EIISKLYIPK RKIISPRSIE DVLPPVEEAV DRCLYLLDRF AQAVTKDKFA LESENISEPY FTNRRTISQQ SAEKLDAACG IDKTENGTLF EDQNVDKEGK ALPATGQKAN VSPEQPPLFT HTVKDSDHIS TRFLGSMDSL TSSEESSERP PLSTLTLKEA DPSSKAAMRR KDSPPPGKVS SQKQPAEKAT SDDKDSVSNI ATEIKEGPIS GTVSSQKQPA EKATSDEKDS VSNIATEIKE GQQSGTVSPQ KQSAWKVIFK KKVSLLNIAT RITGGGKSGT VSSQKQPPSK ATSDKTDSAL NIATEIKDGL QCGTVSSQKQ PALKATTDEE DSVSNIATEI KDGEKSGTVS SQKQPALKAT TDEEDSVSII ATEIKDGEKS GTVSSRKKPA LKATSDEKDS FSNITREKKD GEISRTVTSE KPAGLKATSD EEDSVLNIAR GKEDGEKTRR VSSRKKPALK ATSDEKDSFS NITREKKDGE TSRTVSSQKP PALKATSDEE DSVLNIAREK KDGEKSRTVS SEKPSGLKAT SDEKDSVLNI ARGKKHGEKT RRVSSHKQPA LKATSDKENS VPNMATETKD EQISGTVSSQ KQPALKATSD KKDSVSNIPT EIKDGQQSGT VSSQKQLAWK ATSVKKDSVS NIATEIKDGQ IRGTVSSQRQ PALKATGDEK DSVSNIAREI KDGEKSGTVS PQKQSAQKVI FKKKVSLLNI ATRITGGWKS GTEYPENLPT LKATIENKNS VLNTATKMKD VQTSTPEQDL EMASEGEQKR LEEYENNQPQ VKNQIHSRDD LDDIIQSSQT VSEDGDSLCC NCKNVILLID QHEMKCKDCV HLLKIKKTFC LCKRLTELKD NHCEQLRVKI RKLKNKASVL QKRLSEKEEI KSQLKHETLE LEKELCSLRF AIQQEKKKRR NVEELHQKVR EKLRITEEQY RIEADVTKPI KPALKSAEVE LKTGGNNSNQ VSETDEKEDL LHENRLMQDE IARLRLEKDT IKNQNLEKKY LKDFEIVKRK HEDLQKALKR NEETLAETIA CYSGQLAALT DENTTLRSKL EKQRESGQRL ETEMQSYRCR LNAALCDHDQ SHSSKRDQEL AFQGTVDKCC HLQENLNSHV LILSLQLSKA ESKFRVLETE LHYTGEALKE KALVFEHVQS ELKQKQSQMK DIEKMYKSGY NTMEKCIEKQ ERFCQLKKQN MLLQQQLDDA RNKADNQEKA ILNIQARCDA RVENLQAECR KHRLLLEEDN KMLVNELNHS KEKKCQYEKE KAEREVAVRQ LQQKQDDVLN KRSATKALLD ASSRHCIYLE NGMQDSRKKL DQMRSQFQEI QDQLTATIRC TKEMEGDAQK LEVENVMMRK IIKKQDEQIE RFEKILQHSS LMLQVFES
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