Protein phosphatase 1J (PPM1J)

About Protein phosphatase 1J

Protein phosphatase 1J (PPM1J) is a protein from Homo sapiens identified by UniProt accession Q5JR12, 505 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Protein phosphatase 1J
UniProt accession	Q5JR12
Gene	PPM1J
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

glomerular filtration rate · score 0.42
creatinine measurement · score 0.40
appendicular lean mass · score 0.35
neurodegenerative disease · score 0.29
genetic disorder · score 0.12
aspartate aminotransferase measurement · score 0.08
intraocular pressure measurement · score 0.08
bone density · score 0.07
sex hormone-binding globulin measurement · score 0.07
body height · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5JR12-F1	alphafold	PREDICTED	83.87	—

Amino-acid sequence (505 residues)

MLNRVRSAVA HLVSSGGAPP PRPKSPDLPN AASAPPAAAP EAPRSPPAKA GSGSATPAKA VEARASFSRP TFLQLSPGGL RRADDHAGRA VQSPPDTGRR LPWSTGYAEV INAGKSRHNE DQACCEVVYV EGRRSVTGVP REPSRGQGLC FYYWGLFDGH AGGGAAEMAS RLLHRHIREQ LKDLVEILQD PSPPPLCLPT TPGTPDSSDP SHLLGPQSCW SSQKEVSHES LVVGAVENAF QLMDEQMARE RRGHQVEGGC CALVVIYLLG KVYVANAGDS RAIIVRNGEI IPMSREFTPE TERQRLQLLG FLKPELLGSE FTHLEFPRRV LPKELGQRML YRDQNMTGWA YKKIELEDLR FPLVCGEGKK ARVMATIGVT RGLGDHSLKV CSSTLPIKPF LSCFPEVRVY DLTQYEHCPD DVLVLGTDGL WDVTTDCEVA ATVDRVLSAY EPNDHSRYTA LAQALVLGAR GTPRDRGWRL PNNKLGSGDD ISVFVIPLGG PGSYS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards