About Microtubule-associated tumor suppressor candidate 2
Microtubule-associated tumor suppressor candidate 2 (MTUS2) is a protein
from Homo sapiens identified by UniProt accession
Q5JR59, 1369 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Microtubule-associated tumor suppressor candidate 2 |
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| UniProt accession | Q5JR59 |
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| Gene | MTUS2 |
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| Organism | Homo sapiens |
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| Length | 1369 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.40
- neurofibrillary tangles measurement · score 0.38
- neurodegenerative disease · score 0.34
- DNA methylation · score 0.31
- hypertrophic cardiomyopathy · score 0.29
- hypertension · score 0.18
- adolescent idiopathic scoliosis · score 0.06
- total blood protein measurement · score 0.05
- appendicular lean mass · score 0.05
- central nervous system cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5JR59-F1 | alphafold | PREDICTED | 51.02 | — |
Amino-acid sequence (1369 residues)
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE SKTCDLGDEI GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL SSTIQRELNE EHTVERGTDS LQTTRSIQGP SLSSWRNVMS EASLDVLAKR DAEIPRHVPK DKLAKTLDNE ELRRHSLERA SSSVAAVGSL TPQHPQPLSL DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS VRHPKPSTSE SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG EAHPEATDAL GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS ASLGGADNQP TGKISPCAGE KLGERTSSSF SPGDSHVAFI PNNLTDSKPL DVIEEERRLG SGNKDSVMVL VFNPSVGENK TEVPEPLDPQ SGRSEARESK EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET TVNMTYQPTT PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR NPQALGQVDA SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK PDLQKPRVFS SGLMVSGIKP PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS AKSRILIASQ RSSASAIHPP GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG YSRLPAAKLA AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP AVSSPKRVAA STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR LKERCEQQTR QLGVAQGELK RAICGFDALA VATQHFFRKN ESALVKEKEL SIELANIRDE VAFHTAKCEK LQKEKEELER RFEDEVKRLG WQQQAELQEL EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS HDAALLEMEN NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN QQIHEQEKKI LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ LSEENANLQE YVEKETQEKK RLSRTNEELL WKLQTGDPTS PIKLSPTSPV YRGSSSGPSS PARVSTTPR
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