Dynein light chain Tctex-type 4 (DYNLT4)

About Dynein light chain Tctex-type 4

Dynein light chain Tctex-type 4 (DYNLT4) is a protein from Homo sapiens identified by UniProt accession Q5JR98, 221 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Dynein light chain Tctex-type 4
UniProt accession	Q5JR98
Gene	DYNLT4
Organism	Homo sapiens
Length	221 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

Neurodevelopmental disorder · score 0.11
Blackfan-Diamond anemia · score 0.09
apolipoprotein B measurement · score 0.09
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.07
primary familial polycythemia due to EPO receptor mutation · score 0.07
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
alpha-thalassemia-myelodysplastic syndrome · score 0.06
hemoglobin E-beta-thalassemia syndrome · score 0.06
delta-beta-thalassemia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5JR98-F1	alphafold	PREDICTED	73.28	—

Amino-acid sequence (221 residues)

MASRPLPPGR QEEENAKDSG RKPSPVRPRG CLPSIDEARP AGPGPAPASR RGSMLGLAAS FSRRNSLVGP GAGPGGQRPS LGPVPPLGSR VSFSGLPLAP ARWVAPSYRT EPVPGERWEA ARAQRALEAA LAAGLHDACY SSDEAARLVR ELCEQVHVRL RELSPPRYKL VCSVVLGPRA GQGVHVVSRA LWDVARDGLA SVSYTNTSLF AVATVHGLYC E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards