NHL repeat-containing protein 3 (NHLRC3)

About NHL repeat-containing protein 3

NHL repeat-containing protein 3 (NHLRC3) is a protein from Homo sapiens identified by UniProt accession Q5JS37, 347 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	NHL repeat-containing protein 3
UniProt accession	Q5JS37
Gene	NHLRC3
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

body height · score 0.10
chronic kidney disease · score 0.01
acute kidney failure · score 0.01
Sepsis · score 0.01
hepatocellular carcinoma · score 0.01
calf circumference measurement · score 0.01
neoplasm · score 0.00
type 1 diabetes mellitus · score 0.00
cancer · score 0.00
infect · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5JS37-F1	alphafold	PREDICTED	89.44	—

Amino-acid sequence (347 residues)

MARFWVCVAG AGFFLAFLVL HSRFCGSPVL RNFTFAVSWR TEKILYRLDV GWPKHPEYFT GTTFCVAVDS LNGLVYIGQR GDNIPKILVF TEDGYFLRAW NYTVDTPHGI FAASTLYEQS VWITDVGSGF FGHTVKKYSS FGDLVQVLGT PGKKGTSLNP LQFDNPAELY VEDTGDIYIV DGDGGLNNRL IKLSQDFMIL WLHGENGTGP AKFNIPHSVT LDSAGRVWVA DRGNKRIQVF DKDTGEWLGA WNNCFTEEGP SSVRFTPDGK YLIVAQLNLS RLSVVAAPPV GSIGECSVIS TIQLADQVLP HLLEVDRKTG AVYVAEIGAK QVQKYVPLNS YVPSFGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards