About Integrator complex subunit 6-like
Integrator complex subunit 6-like (INTS6L) is a protein
from Homo sapiens identified by UniProt accession
Q5JSJ4, 861 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Integrator complex subunit 6-like |
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| UniProt accession | Q5JSJ4 |
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| Gene | INTS6L |
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| Organism | Homo sapiens |
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| Length | 861 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- Moebius syndrome · score 0.11
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.05
- Adult-onset autosomal recessive sideroblastic anemia · score 0.04
- microcytic anemia with liver iron overload · score 0.04
- Combined hyperlipidemia · score 0.04
- congenital dyserythropoietic anemia type 4 · score 0.04
- Congenital dyserythropoietic anemia type IV · score 0.04
- IRIDA syndrome · score 0.04
- hypertriglyceridemia 2 · score 0.04
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5JSJ4-F1 | alphafold | PREDICTED | 67.76 | — |
Amino-acid sequence (861 residues)
MPILLFLIDT SASMNQRTDL GTSYLDIAKG AVELFLKLRA RDPASRGDRY MLVTYDEPPY CIKAGWKENH ATFMSELKNL QASGLTTLGQ ALRSSFDLLN LNRLISGIDN YGQGRNPFFL EPSILITITD GNKLTSTAGV QEELHLPLNS PLPGSELTKE PFRWDQRLFA LVLRLPGVAS TEPEQLGSVP TDESAITQMC EVTGGRSYCV RTQRMLNQCL ESLVQKVQSG VVINFEKTGP DPLPIGEDGL MDSSRPSNSF AAQPWHSCHK LIYVRPNSKT GVPVGHWPIP ESFWPDQNLP SLPPRTSHPV VRFSCVDCEP MVIDKLPFDK YELEPSPLTQ YILERKSPHT CWQVFVTSSG KYNELGYPFG YLKASTTLTC VNLFVMPYNY PVLLPLLDDL FKVHKLKPNL KWRQAFDSYL KTLPPYYLLT KLESERILAS VGKKPPQEIG IKVKNHSGGG MSLTHNKNFR KLLKEITGET ALRLTELNTK EFAGFQIGLL NKDLKPQTYR NAYDIPRRGL LDQLTRMRSN LLKTHKFIVG QDEDSLHSVP VAQMGNYQEY LKTLASPLRE IDPDQPKRLH TFGNPFKQDK KGMMIDEADE FVAGPQNKVK RPGEPNSPMS SKRRRSMSLL LRKPQTPPTV TNHVGGKGPP SASWFPSYPN LIKPTLVHTD ATIIHDGHEE KMENGQITPD GFLSKSAPSE LINMTGDLMP PNQVDSLSDD FTSLSKDGLI QKPGSNAFVG GAKNCSLSVD DQKDPVASTL GAMPNTLQIT PAMAQGINAD IKHQLMKEVR KFGRKYERIF ILLEEVQGPL EMKKQFVEFT IKEAARFKRR VLIQYLEKVL EKINSHHLHN NISHINSRSS C
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