Meiosis expressed gene 1 protein homolog (MEIG1)

About Meiosis expressed gene 1 protein homolog

Meiosis expressed gene 1 protein homolog (MEIG1) is a protein from Homo sapiens identified by UniProt accession Q5JSS6, 88 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Meiosis expressed gene 1 protein homolog
UniProt accession	Q5JSS6
Gene	MEIG1
Organism	Homo sapiens
Length	88 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

azoospermia · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.10
spermatogenic failure 65 · score 0.09
partial chromosome Y deletion · score 0.09
spermatogenic failure 56 · score 0.09
spermatogenic failure, X-linked, 3 · score 0.09
spermatogenic failure 72 · score 0.09
spermatogenic failure 40 · score 0.09
spermatogenic failure 46 · score 0.09
spermatogenic failure 18 · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5JSS6-F1	alphafold	PREDICTED	85.07	—

Amino-acid sequence (88 residues)

MASSDVKPKS VSHAKKWSEE IENLYRFQQA GYRDETEYRQ VKQVSMVDRW PETGYVKKLQ RRDNTFYYYN KQRECDDKEV HKVKIYAY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards