Protein PRRC2B (PRRC2B)

About Protein PRRC2B

Protein PRRC2B (PRRC2B) is a protein from Homo sapiens identified by UniProt accession Q5JSZ5, 2229 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Protein PRRC2B
UniProt accession	Q5JSZ5
Gene	PRRC2B
Organism	Homo sapiens
Length	2229 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

urate measurement · score 0.28
bone density · score 0.24
uric acid measurement · score 0.17
smoking status measurement · score 0.09
antisocial behaviour measurement · score 0.07
substance abuse · score 0.07
attention deficit hyperactivity disorder · score 0.07
electrocardiography · score 0.06
fat body mass · score 0.05
chronic obstructive pulmonary disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5JSZ5-F1	alphafold	PREDICTED	38.01	—

Amino-acid sequence (2229 residues)

MSDRLGQITK GKDGKSKYST LSLFDKYKGK SVDAIRSSVI PRHGLQSLGK VAAARRMPPP ANLPSLKSEN KGNDPNIVIV PKDGTGWANK QDQQDPKSSS ATASQPPESL PQPGLQKSVS NLQKPTQSIS QENTNSVPGG PKSWAQLNGK PVGHEGGLRG SSRLLSFSPE EFPTLKAAGG QDKAGKEKGV LDLSYGPGPS LRPQNVTSWR EGGGRHIISA TSLSTSPTEL GSRNSSTGDG APSSACTSDS KDPSLRPAQP VRKGASQFMG NVYHPPTYHD MLPAFMCSPK SSENQGTVER GSFPLPQLRL EPRVPFRQFQ MNDQDGKENR LGLSRPLRPL RQLVERAPRP TIINAENLKG LDDLDADADD GWAGLHEEVD YSEKLKFSDD EEEEEVVKDG RPKWNSWDPR RQRQLSMSSA DSADAKRTRE EGKDWAEAVG ASRVVRKAPD PQPPPRKLHG WAPGPDYQKS SMGSMFRQQS IEDKEDKPPP RQKFIQSEMS EAVERARKRR EEEERRAREE RLAACAAKLK QLDQKCKQAR KAGEARKQAE KEVPWSPSAE KASPQENGPA VHKGSPEFPA QETPTTFPEE APTVSPAVAQ SNSSEEEARE AGSPAQEFKY QKSLPPRFQR QQQQQQQEQL YKMQHWQPVY PPPSHPQRTF YPHHPQMLGF DPRWMMMPSY MDPRITPTRT PVDFYPSALH PSGLMKPMMP QESLNGTGCR SEDQNCVPPL QERKVTPIDS PPVWSPEGYM ALQSKGYPLP HPKSSDTLAM DMRVRNESSF SASLGRAGGV SAQRDLFEER GEEYLSAFDK KAQADFDSCI SSQRIGQELL FPPQENVQDA GAPGGHTQNL RCSPLEPDFV PDEKKPECGS WDVSHQPETA DTAHGVERET PREGTAFNIS SWDKNGSPNK QPSSEPEWTP EPRSSSSQHP EQTGRTRRSG PIKKPVLKAL KVEDKEKELE KIKQELGEES TRLAKEKEQS PTAEKDEDEE NDASLANSST TTLEDKGPGH ATFGREATKF EEEEKPDKAW EARPPRESSD VPPMKRNNWI FIDEEQAFGV RGQARGRGRG FREFTFRGRP AGGNGSGLCG GGVLGARSIY CSSQRSGRGR GLREFARPED CPRAKPRRRV ASETHSEGSE YEELPKRRRQ RGSENGNEGS LLEREESTLK KGDCRDSWRS NKGCSEDHSG LDAKSRGPRA FGRALPPRLS NCGYGRRTFV SKESPHWQSK SPGSSWQEYG PSDTCGSRRP TDRDYVPDSY RHPDAFGGRG FEDSRAEDKR SFFQDEHVAD SENAENRPFR RRRPPRQDKP PRFRRLRQER ESLGLWGPEE EPHLLAGQWP GRPKLCSGDK SGTVGRRSPE LSYQNSSDHA NEEWETASES SDFSERRERR EGPGSEPDSQ VDGGLSGASL GEKKELAKRS FSSQRPVVDR QSRKLEPGGF GEKPVRPGGG DTSPRYESQQ NGTPLKVKRS PDEALPGGLS GCSSGSGHSP YALERAAHAS ADLPEASSKK AEKEAKLAAP RAGEQGEAMK QFDLNYGSAI IENCGSSPGE ESEVGSMVGE GFIEVLTKKQ RRLLEEERRK KEQAVQVPVK GRGLSSRIPP RFAKKQNNLC LEQGDVTVPG SSLGTEIWES SSQALPVQAP ANDSWRKAVT AFSSTETGSA EQGFKSSQGD SGVDLSAESR ESSATSSQRS SPYGTLKPEE MSGPGLAEPK ADSHKEQAPK PSEQKDSEQG SGQSKEHRPG PIGNERSLKN RKGSEGAERL QGAVVPPVNG VEIHVDSVLP VPPIEFGVSP KDSDFSLPPG SASGPTGSPV VKLQDALASN AGLTQSIPIL RRDHHIQRAI GLSPMSFPTA DLTLKMESAR KAWENSPSLP EQSSPGGAGS GIQPPSSVGA SSGVNYSSFG GVSMPPMPVA SVAPSASMPG SHLPPLYLDG HVFASQPRLV PQTIPQQQSY QQAAAAQQIP ISLHTSLQAQ AQLGLRGGLP VSQSQEIFSS LQPFRSQVYM HPSLSPPSTM ILSGGTALKP PYSAFPGMQP LEMVKPQSGS PYQPMSGNQA LVYEGQLSQA AGLGASQMLD SQLPQLTMPL PRYGSGQQPL ILPQSIQLPP GQSLSVGAPR RIPPPGSQPP VLNTSREPSQ MEMKGFHFAD SKQNVPSGGP VPSPQTYRPS SASPSGKPSG SAVNMGSVQG HYVQQAKQRV DEKPSLGAVK LQEAPSAASQ MKRTGAIKPR AVKVEESKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards