About Zinc-regulated GTPase metalloprotein activator 1C
Zinc-regulated GTPase metalloprotein activator 1C (ZNG1C) is a protein
from Homo sapiens identified by UniProt accession
Q5JTY5, 395 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Zinc-regulated GTPase metalloprotein activator 1C |
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| UniProt accession | Q5JTY5 |
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| Gene | ZNG1C |
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| Organism | Homo sapiens |
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| Length | 395 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- congenital hydronephrosis · score 0.07
- ureteral neoplasm · score 0.07
- ureter cancer · score 0.07
- ureterocele · score 0.07
- familial vesicoureteral reflux · score 0.06
- congenital primary megaureter · score 0.06
- multicystic dysplastic kidney · score 0.06
- Genetic renal or urinary tract malformation · score 0.06
- renal hypodysplasia/aplasia 3 · score 0.06
- Ochoa syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5JTY5-F1 | alphafold | PREDICTED | 75.38 | — |
Amino-acid sequence (395 residues)
MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
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