About FERM and PDZ domain-containing protein 3
FERM and PDZ domain-containing protein 3 (FRMPD3) is a protein
from Homo sapiens identified by UniProt accession
Q5JV73, 1777 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | FERM and PDZ domain-containing protein 3 |
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| UniProt accession | Q5JV73 |
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| Gene | FRMPD3 |
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| Organism | Homo sapiens |
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| Length | 1777 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (10)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.10
- major depressive disorder · score 0.02
- Ataxia-telangiectasia · score 0.01
- Low-frequency sensorineural hearing impairment · score 0.01
- Friedreich ataxia · score 0.01
- brucellosis · score 0.01
- ulcerative colitis · score 0.00
- COVID-19 · score 0.00
- Huntington disease · score 0.00
- Crohn's disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5JV73-F1 | alphafold | PREDICTED | 51.03 | — |
Amino-acid sequence (1777 residues)
MQEESANDME CEQLPAEILR QVTVHRDPIY GFGFVAGSER PVVVRSVRPG GPSENKLLAG DQIVAINEED VSEAPRERLI ELIRSAKEFI VLTVLHTHQS PKSAFISAAK KAKLRSNPVK VRFSEQVAVG ETDAKMMKKE ALLLIPNVLK VFLENGQIKS FTFDGRTTVK DVMLTLQDRL SLRFIEHFAL VLEYAGPEQN HKFLLLQDKQ PLAYVVQRTH YHGMKCLFRI SFFPKDPVEL LRRDPAAFEY LYIQSRNDVI RERFGMDPKP EMLLGLAALH IYITVSATRP SQKISLKNVE KEWGLEPFLP PSLLQVIKEK NLRKSLSQQL KAHQTHPSCG TKGSAIQAKL QYLRILNELP TFTGVLFNTV GLDEKQSATT LLVGPRHGIS HVIDLKTNLT TVLSEFSKIS KIQLFRENQG VARVETSIMD AKPLVLLMEW PEATNFACLI AGYCRLLLDS RKMVFSRPAS QPLPPPMIKA DYMHSAHRPV TGGHLGKKES SYVGSVGTSP RKSSRCTPPP ADSELVSFCY LHMREQRKEQ ESRTDVNENL IFFEETRPRT KSDPTSKSSG QGYEVVPDDF DAASLDHEPC ASRARSYTLD NSLGAEALNF YCDSCKAKLQ EQLGPRKGGK PGSSRDNIVD LMSLPPPGSE EEEEEEDETT SLLPAIAAPP PGFRDNSSDE DDPKRRAVQS QEQGRHLRGL LYDEIPVTLI DSVQTRTVRD HAQELDDALV STLQALEALA ASEDGPHPPP PQTAGLIVLA TITPESSLDS GHETNSSELT DMSEMMSAMK QHQNTTYFLA QHLNKDSLLA RKDLPFRIQS CAAQAVLTAP YSLGRPDPNP SLQPIATGQS PGPPGARRKL PQSEGQVQGE RTYSLAVHPA LSPQLSEQKN LSLLSPVPED KGPGHTRAGL EMSLRAATSS LSEEQVSELR DNLPKEVRLS PKLILDPKSS VTPAIISAAL QQVVHNKSLV TAGGALGNPP SRGERRLEAS MGRPEVSMMS SSASKNLKFK ISPSAPETSW NSQHQLGAEV SSSPRAPTGS RADSLHLSQQ EDSLPVQNFP PKSYLLRTSR ESVGKQATGE VAGKGGPVGG KPTLQKQGTI SSQGEKAQLE STPKRSKLEE TSLVPRATYP MALQSPSCQS RSHSPSCQPH GHSPSSQSRG QSPSCQPRGQ SPLRSQAASR QVSTMPSRKL ETTLNGAHST SEGPAKPKSS RGPFRLRNLF SATFPTRQKK ETDERQAQLQ KVKQYELEFL EELLKPPSQG ELPGTEYLQP PAPGRCSCQL RSSPVQQGPG MSREQRRSCD CKRICRGGRP QATQTPVPSL RGRERDRVLP SQRQPEAGPG VSLSSPINVQ RIRSTSLESR ECRSDPESGV SCLTTCASGG ECLGAPNYRK LMRRYSISEL DQGDRASLTS DVYPHPPLGM LPREAKEVEA SLPIALGPKS RSLESPTLGD PSYVQVAPET KGPRQMAVFS LPEEVYRKPA ELDEDSESSK CCSIRYCFYY RKCDMADDAS DGKDELSYSI PMKILPGMKL DEQVVPVVSR TLQVLDAATC SSSSPEASRT QEIDLRVSTF EGSLAKINAL RAHAYGLPDG FLAARLDTNE LLTVLRQCVA SPEARAPKPY VSQISEYKLE LALKFKELRA SCRRVANVDK SPTHMLAAIT GSFQVLSSLI ETFVRLVFIV RSEAQRQELL AKVEEVVRNY TFLLRAAEES TARNLNQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQVAAAAGA ATEHPPGSPT SATVMSTFTH SLKTLIK
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