Probable methyltransferase-like protein 24 (METTL24)

About Probable methyltransferase-like protein 24

Probable methyltransferase-like protein 24 (METTL24) is a protein from Homo sapiens identified by UniProt accession Q5JXM2, 366 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Probable methyltransferase-like protein 24
UniProt accession	Q5JXM2
Gene	METTL24
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.37
mean platelet volume · score 0.33
platelet count · score 0.17
platelet component distribution width · score 0.13
neoplasm · score 0.05
mean corpuscular hemoglobin concentration · score 0.05
IRIDA syndrome · score 0.04
Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
Rh deficiency syndrome · score 0.03
congenital dyserythropoietic anemia type 4 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5JXM2-F1	alphafold	PREDICTED	77.91	—

Amino-acid sequence (366 residues)

MARERPPGRG CGVLRRCLLG AVLLFGLRLC AELRRAGPGS PTRSAPPGPA WRPPGPHLPP APGQPRGASR RQVTYVRSGR RAPPGGGGSG TPEPGCCAPR GRPRRKGPRW HIDLQPWAGS AQSLDEEAWR FLRYISTTQI ACNHMNTDSL ATDSSPTHKP WSVCLDDRFN LAHQIRNKQC RLYSLGLGSD DTHFEVSMAN NGCEVHRFDP SVKSAHILES QHLWYHRLSI DWRDPHPAVA AQKPHSNTRK LGSILNEFGH HKIDVLKADL ESAEWKVLEN LILEDVLEQI GQLIFEIHLH WPGFEVSGSD SSVVRFWYSL LKELEQKDFR LFHSYKDLSK PQLFLKKDIF NASSCYTLSW VNTRWK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards