E3 ubiquitin-protein ligase RNFT1 (RNFT1)

About E3 ubiquitin-protein ligase RNFT1

E3 ubiquitin-protein ligase RNFT1 (RNFT1) is a protein from Homo sapiens identified by UniProt accession Q5M7Z0, 435 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNFT1
UniProt accession	Q5M7Z0
Gene	RNFT1
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
pulse pressure measurement · score 0.26
Red cell distribution width · score 0.25
erythrocyte count · score 0.20
red blood cell density measurement · score 0.20
monocyte count · score 0.19
mean reticulocyte volume · score 0.15
serum albumin measurement · score 0.15
hematocrit · score 0.15
bilirubin measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5M7Z0-F1	alphafold	PREDICTED	71.61	—

Amino-acid sequence (435 residues)

MPLFLLSLPT PPSASGHERR QRPEAKTSGS EKKYLRAMQA NRSQLHSPPG TGSSEDASTP QCVHTRLTGE GSCPHSGDVH IQINSIPKEC AENASSRNIR SGVHSCAHGC VHSRLRGHSH SEARLTDDTA AESGDHGSSS FSEFRYLFKW LQKSLPYILI LSVKLVMQHI TGISLGIGLL TTFMYANKSI VNQVFLRERS SKIQCAWLLV FLAGSSVLLY YTFHSQSLYY SLIFLNPTLD HLSFWEVFWI VGITDFILKF FFMGLKCLIL LVPSFIMPFK SKGYWYMLLE ELCQYYRTFV PIPVWFRYLI SYGEFGNVTR WSLGILLALL YLILKLLEFF GHLRTFRQVL RIFFTQPSYG VAASKRQCSD VDDICSICQA EFQKPILLIC QHIFCEECMT LWFNREKTCP LCRTVISDHI NKWKDGATSS HLQIY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards