About Ectonucleoside triphosphate diphosphohydrolase 8
Ectonucleoside triphosphate diphosphohydrolase 8 (ENTPD8) is a protein
from Homo sapiens identified by UniProt accession
Q5MY95, 495 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Ectonucleoside triphosphate diphosphohydrolase 8 |
|---|
| UniProt accession | Q5MY95 |
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| Gene | ENTPD8 |
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| Organism | Homo sapiens |
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| Length | 495 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- hip bone size · score 0.35
- hip bone mineral density · score 0.28
- neurodegenerative disease · score 0.13
- Barrett's esophagus · score 0.06
- inflammatory bowel disease · score 0.06
- Autosomal recessive early-onset inflammatory bowel disease · score 0.05
- colitis · score 0.05
- pneumonia · score 0.04
- ulcerative colitis · score 0.04
- inflammatory bowel disease 30 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5MY95-F1 | alphafold | PREDICTED | 94.36 | — |
Amino-acid sequence (495 residues)
MGLSRKEQVF LALLGASGVS GLTALILLLV EATSVLLPTD IKFGIVFDAG SSHTSLFLYQ WLANKENGTG VVSQALACQV EGPGISSYTS NAAQAGESLQ GCLEEALVLI PEAQHRKTPT FLGATAGMRL LSRKNSSQAR DIFAAVTQVL GRSPVDFWGA ELLAGQAEGA FGWITVNYGL GTLVKYSFTG EWIQPPEEML VGALDMGGAS TQITFVPGGP ILDKSTQADF RLYGSDYSVY THSYLCFGRD QMLSRLLVGL VQSRPAALLR HPCYLSGYQT TLALGPLYES PCVHATPPLS LPQNLTVEGT GNPGACVSAI RELFNFSSCQ GQEDCAFDGV YQPPLRGQFY AFSNFYYTFH FLNLTSRQPL STVNATIWEF CQRPWKLVEA SYPGQDRWLR DYCASGLYIL TLLHEGYGFS EETWPSLEFR KQAGGVDIGW TLGYMLNLTG MIPADAPAQW RAESYGVWVA KVVFMVLALV AVVGAALVQL FWLQD
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