About EGF domain-specific O-linked N-acetylglucosamine transferase
EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT) is a protein
from Homo sapiens identified by UniProt accession
Q5NDL2, 527 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | EGF domain-specific O-linked N-acetylglucosamine transferase |
|---|
| UniProt accession | Q5NDL2 |
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| Gene | EOGT |
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| Organism | Homo sapiens |
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| Length | 527 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- Adams-Oliver syndrome · score 0.75
- diet measurement · score 0.35
- serum urea measurement · score 0.20
- genetic disorder · score 0.19
- mean corpuscular volume · score 0.15
- mean corpuscular hemoglobin · score 0.12
- mean corpuscular hemoglobin concentration · score 0.04
- Familial exudative vitreoretinopathy · score 0.04
- urate measurement · score 0.04
- sex hormone-binding globulin measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5NDL2-F1 | alphafold | PREDICTED | 91.49 | — |
Amino-acid sequence (527 residues)
MLMLFVFGVL LHEVSLSGQN EAPPNTHSIP GEPLYNYASI RLPEEHIPFF LHNNRHIATV CRKDSLCPYK KHLEKLKYCW GYEKSCKPEF RFGYPVCSYV DMGWTDTLES AEDIFWKQAD FGYARERLEE MHVLCQPKET SDSSLVCSRY LQYCRATNLY LDLRNIKRNH DRFKEDFFQS GEIGGHCKLD IRTLTSEGQR KSPLQSWFAE LQSYTQLNFR PIEDAKCDIV IEKPTYFMKL DAGVNMYHHF CDFINLYITQ HVNNSFSTDV YIVMWDTSSY GYGDLFSDTW NAFTDYDVIH LKTYDSKRVC FKEAVFSLLP RMRYGLFYNT PLISGCQNTG LFRAFAQHVL HRLNITQEGP KDGKIRVTIL ARSTEYRKIL NQNELVNALK TVSTFEVQIV DYKYRELGFL DQLRITHNTD IFIGMHGAGL THLLFLPDWA AVFELYNCED ERCYLDLARL RGVHYITWRR QNKVFPQDKG HHPTLGEHPK FTNYSFDVEE FMYLVLQAAD HVLQHPKWPF KKKHDEL
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