Neurite extension and migration factor (NEXMIF)

About Neurite extension and migration factor

Neurite extension and migration factor (NEXMIF) is a protein from Homo sapiens identified by UniProt accession Q5QGS0, 1516 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	Neurite extension and migration factor
UniProt accession	Q5QGS0
Gene	NEXMIF
Organism	Homo sapiens
Length	1516 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

X-linked intellectual disability, Cantagrel type · score 0.78
genetic disorder · score 0.50
Intellectual disability · score 0.50
myoclonic-astatic epilepsy · score 0.37
X-linked complex neurodevelopmental disorder · score 0.37
continuous spikes and waves during sleep · score 0.34
Neurodevelopmental disorder · score 0.27
developmental and epileptic encephalopathy · score 0.09
azoospermia · score 0.09
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5QGS0-F1	alphafold	PREDICTED	40.59	—

Amino-acid sequence (1516 residues)

MDNQQDKAIV ASANGENTLI NGVKENDSED QDVAMKSFAA LEAAAPIQPT PVAQKETLMY PRGLLPLPSK KPCMQSPPSP LGLIEAPEHA ANSASVNAIS LTSGIAKGLN TWSLPNECEK APFAIMEPAG MSALNGDCLM QPSRTCLGCF MESKDAVDPE PGISLKVGDL NRDYETCAVS DIGIQCINAG ENMKYGEQLL SDQLLGFPLH KSRAGDRRET EKPDIDLEDP AQKSYYEALL LDKCNTEEAL LANSNQDWGY FETFISESKI ELLDLCSKNE LSVNLFSEED VDNYMFDDDE STLGSDVCSL KIRYESFQDN VRDKTTLLMQ EDAQFNFFPS VFTTCPKRES KSGALKQSSD FSQFKVPDVS IIWGEEDKNL DKKKGKEEGQ EDKGVEKKDG KDNGEKPALN KPCSGTEVEQ LKNPKQGHLA NSLETSGSFS DDSSFIEISY DAMGEIKDCS RYMARDTNSG SSSSQQNYGL RAKRKVRYSE DYLYDVDSLE GEKVNERKEW LPVGSKEEDD DEWCPKKRRK VTRKEPPVII KYIIINRFKG EKNMLVKLGK VDASETTVNL SENQLNKYAK LAPLKGFWQK KKKQRNTNTD SIKTPFSQKQ SFEPGSFEVS FLPPARKRKS KLGNRHRIQR IPSIEISASS KQISLCNDQR HASNHKEDGG LKGTLKSAPL GAPSCANGSH LNDITGPDSV KVKAQDTEFK GPERKVLNKI KFKSEARLKS KKVKAAGQES KPIVQMSPLL ENQSSKANLK NEVIPGTSNS SRLSEFHEAK AAKSSTFLPT TCSSEMPLSS ANVTTNIPVI PGGYLQTLLD ASDLSNNTSI SYFSHHSPEQ NEGSLTQTEK SFVPLQPTQD CVLTSSSDSE LQQSSHNFKM ESSNYRNVWP NKATSGTQEF MAEVSREIAP TQSSEFGASQ VVSMENNLTP TTYNPICLNS GGSNCNKVLY DSMQDTQLPS DDSYQLCHFN NGEICFPFQQ GPVNMDDGRL FSFDSMAPLS VSSSNYCSLS LKSCEKDGDD DITDDFLAHC SPKLVIQQSI DEIAPLKEST DLLDISNFTP DKFRHSSLSE MSPPDTPSLS PQITRCESMK TLGTLKGFQE GVPGPLDSVE KIKWDCSTLS RQVQMEDGFT LNNHQFQFHM FNDEDSVSLL QKNPCLSTFN DPSGQISTNN KVSKSRKKSS PSKSGAMNQS SSQKNTRKKS LKGNNKGIEK PPGKNSRQVP KSTKKGKYMA AINGEKMQIG IGRGGSQTNT ISSTGKTLAE CIQHGGPMAS MKMPSQKGLS GDWALGKESS PGWSDMSMGT NTNSLLDDDQ REFQEPSYIL SNIASGMADV QRFMMASIEP LWEPMEHHGD PNIFYSPESN SLKLKTLKIL AGTPQESKKK INSGSQGATK NHRSIKGVSK SNGKTAIGDP GRANMPGYNE DSRSTFFDKK YSNMSTLGNN GPTHKKLYRH KSSSKALRDE KCKGKHMERE QVHKDESGTA SFEKLRDSDY NLLKAETTFW VLPVFEEETR IFQKDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards