About Trichohyalin-like protein 1
Trichohyalin-like protein 1 (TCHHL1) is a protein
from Homo sapiens identified by UniProt accession
Q5QJ38, 904 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Trichohyalin-like protein 1 |
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| UniProt accession | Q5QJ38 |
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| Gene | TCHHL1 |
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| Organism | Homo sapiens |
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| Length | 904 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- asthma · score 0.19
- seasonal allergic rhinitis · score 0.17
- bladder exstrophy · score 0.12
- hair morphology · score 0.10
- Eczematoid dermatitis · score 0.08
- hair morphology measurement · score 0.07
- allergic rhinitis · score 0.07
- squamous cell carcinoma · score 0.06
- vitamin D measurement · score 0.05
- susceptibility to plantar warts measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5QJ38-F1 | alphafold | PREDICTED | 42.00 | — |
Amino-acid sequence (904 residues)
MPQLLRNVLC VIETFHKYAS EDSNGATLTG RELKQLIQGE FGDFFQPCVL HAVEKNSNLL NIDSNGIISF DEFVLAIFNL LNLCYLDIKS LLSSELRQVT KPEKEKLDDV DVQATTGDGQ WTVGTSPTQE KRMLPSGMAS SSQLIPEESG AVGNNRVDPW REAKTHNFPG EASEHNDPKN KHLEGDEQSQ EVAQDIQTTE DNEGQLKTNK PMAGSKKTSS PTERKGQDKE ISQEGDEPAR EQSVSKIRDQ FGEQEGNLAT QSSPPKEATQ RPCEDQEVRT EKEKHSNIQE PPLQREDEPS SQHADLPEQA AARSPSQTQK STDSKDVCRM FDTQEPGKDA DQTPAKTKNL GEPEDYGRTS ETQEKECETK DLPVQYGSRN GSETSDMRDE RKERRGPEAH GTAGQKERDR KTRPLVLETQ TQDGKYQELQ GLSKSKDAEK GSETQYLSSE GGDQTHPELE GTAVSGEEAE HTKEGTAEAF VNSKNAPAAE RTLGARERTQ DLAPLEKQSV GENTRVTKTH DQPVEEEDGY QGEDPESPFT QSDEGSSETP NSLASEEGNS SSETGELPVQ GDSQSQGDQH GESVQGGHNN NPDTQRQGTP GEKNRALEAV VPAVRGEDVQ LTEDQEQPAR GEHKNQGPGT KGPGAAVEPN GHPEAQESTA GDENRKSLEI EITGALDEDF TDQLSLMQLP GKGDSRNELK VQGPSSKEEK GRATEAQNTL LESLDEDNSA SLKIQLETKE PVTSEEEDES PQELAGEGGD QKSPAKKEHN SSVPWSSLEK QMQRDQEPCS VERGAVYSSP LYQYLQEKIL QQTNVTQEEH QKQVQIAQAS GPELCSVSLT SEISDCSVFF NYSQASQPYT RGLPLDESPA GAQETPAPQA LEDKQGHPQR ERLVLQREAS TTKQ
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