About Tubulin-specific chaperone cofactor E-like protein
Tubulin-specific chaperone cofactor E-like protein (TBCEL) is a protein
from Homo sapiens identified by UniProt accession
Q5QJ74, 424 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Tubulin-specific chaperone cofactor E-like protein |
|---|
| UniProt accession | Q5QJ74 |
|---|
| Gene | TBCEL |
|---|
| Organism | Homo sapiens |
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| Length | 424 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (15)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.06
- neuritic plaque measurement · score 0.06
- metabolite measurement · score 0.06
- Leber congenital amaurosis · score 0.05
- retinitis pigmentosa 71 · score 0.04
- coloboma of optic nerve · score 0.04
- pseudotumor cerebri · score 0.03
- optic atrophy 13 with retinal and foveal abnormalities · score 0.03
- auditory neuropathy-optic atrophy syndrome · score 0.03
- Optic neuropathy · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5QJ74-F1 | alphafold | PREDICTED | 89.86 | — |
Amino-acid sequence (424 residues)
MDQPSGRSFM QVLCEKYSPE NFPYRRGPGM GVHVPATPQG SPMKDRLNLP SVLVLNSCGI TCAGDEKEIA AFCAHVSELD LSDNKLEDWH EVSKIVSNVP QLEFLNLSSN PLNLSVLERT CAGSFSGVRK LVLNNSKASW ETVHMILQEL PDLEELFLCL NDYETVSCPS ICCHSLKLLH ITDNNLQDWT EIRKLGVMFP SLDTLVLANN HLNAIEEPDD SLARLFPNLR SISLHKSGLQ SWEDIDKLNS FPKLEEVRLL GIPLLQPYTT EERRKLVIAR LPSVSKLNGS VVTDGEREDS ERFFIRYYVD VPQEEVPFRY HELITKYGKL EPLAEVDLRP QSSAKVEVHF NDQVEEMSIR LDQTVAELKK QLKTLVQLPT SNMLLYYFDH EAPFGPEEMK YSSRALHSFG IRDGDKIYVE SKTK
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