Zinc-regulated GTPase metalloprotein activator 1E…

About Zinc-regulated GTPase metalloprotein activator 1E

Zinc-regulated GTPase metalloprotein activator 1E (ZNG1E) is a protein from Homo sapiens identified by UniProt accession Q5RIA9, 395 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	Zinc-regulated GTPase metalloprotein activator 1E
UniProt accession	Q5RIA9
Gene	ZNG1E
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

congenital hydronephrosis · score 0.07
ureteral neoplasm · score 0.07
ureter cancer · score 0.07
ureterocele · score 0.07
familial vesicoureteral reflux · score 0.06
congenital primary megaureter · score 0.06
multicystic dysplastic kidney · score 0.06
Genetic renal or urinary tract malformation · score 0.06
renal hypodysplasia/aplasia 3 · score 0.06
Ochoa syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5RIA9-F1	alphafold	PREDICTED	75.13	—

Amino-acid sequence (395 residues)

MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DDILLETTGL ADPGAVTSMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADII LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLI GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Zinc-regulated GTPase metalloprotein activator 1E (ZNG1E)