RNA-binding protein 48 (RBM48)

About RNA-binding protein 48

RNA-binding protein 48 (RBM48) is a protein from Homo sapiens identified by UniProt accession Q5RL73, 367 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	RNA-binding protein 48
UniProt accession	Q5RL73
Gene	RBM48
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

nephronophthisis · score 0.26
neurodegenerative disease · score 0.18
body height · score 0.16
lymphocyte count · score 0.12
granulocyte percentage of myeloid white cells · score 0.10
heel bone mineral density · score 0.07
bone quantitative ultrasound measurement · score 0.06
bone density · score 0.06
ulcer disease · score 0.05
mean corpuscular volume · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5RL73-F1	alphafold	PREDICTED	67.73	—

Amino-acid sequence (367 residues)

MASSGGELGS LFDHHVQRAV CDTRAKYREG RRPRAVKVYT INLESQYLLI QGVPAVGVMK ELVERFALYG AIEQYNALDE YPAEDFTEVY LIKFMNLQSA RTAKRKMDEQ SFFGGLLHVC YAPEFETVEE TRKKLQMRKA YVVKTTENKD HYVTKKKLVT EHKDTEDFRQ DFHSEMSGFC KAALNTSAGN SNPYLPYSCE LPLCYFSSKC MCSSGGPVDR APDSSKDGRN HHKTMGHYNH NDSLRKTQIN SLKNSVACPG AQKAITSSEA VDRFMPRTTQ LQERKRRRED DRKLGTFLQT NPTGNEIMIG PLLPDISKVD MHDDSLNTTA NLIRHKLKEV ISSVPKPPED KPEDVHTSHP LKQRRRI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards