About Dapper homolog 2
Dapper homolog 2 (DACT2) is a protein
from Homo sapiens identified by UniProt accession
Q5SW24, 774 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Dapper homolog 2 |
|---|
| UniProt accession | Q5SW24 |
|---|
| Gene | DACT2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 774 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.28
- neurofibrillary tangles measurement · score 0.15
- breast cancer · score 0.08
- papillary thyroid carcinoma · score 0.08
- neoplasm · score 0.07
- hepatocellular carcinoma · score 0.07
- atrial fibrillation · score 0.06
- body height · score 0.06
- BMI-adjusted waist circumference · score 0.05
- sitting height measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5SW24-F1 | alphafold | PREDICTED | 50.30 | — |
Amino-acid sequence (774 residues)
MWTPGGPPGS AGWDRRRLGA RLRAAFAGLQ ELQGLRATQQ ERVRGALALQ PPPAPAAPCG PHGLHGPEQQ LEAALAALQE QLSRLRQQDI GLKTHLDQLD LQISKLQLDV GTASGEALDS DSRPSSGFYE MSDGGSCSLS TSCASVCSDH ISPSLGSLLP VAQAHKARPS MGDWRPRSVD ETTVPAWRPQ ATEEGARPPG SVEDAGQPWG TFWPRPVSTG DLDRALPADT GLQKASADAE LLGLLCQGVD IPLHVPDPKY RQDLVSQGGR EVYPYPSPLH AVALQSPLFV LTKETPQRGG PSFPRESPRG PAGLNTIQTG PVLEAGPARA RAYIDRLLHL WGRETPAKGS EGEQGPLRHA ASPSPQRQGG WSTDGGGRLL VFAPGREDEG GPAQSRGAGR GGPQQQGYMP LEGPQQSGSL PEEGSKPSNS CVLRETMVQA SPSSKAQQTP SAQDYGRGNI ISPSRMLDKS PSPASGHFAH PSFAASLKMG PPKSKAEKIK RSPMDKVLRF ARQPLLLLDR PEGAHAAPQP SLEWDPAHWP TGRGGLQRRP ALAWEAPGRS CSESTLYPMP VLVPLAVAPQ ESHRTSAQAL FPFEASLLTS VARRKHRRWQ STVEISARAR LASCPESNLG PPRPVARRAG GPLARGRPSL VRQDAYTRSD SEPSKHSAEC DPRFPSVIPE TSEGESSDHT TNRFGDRESS SSDEEGGAQS RDCDLALGYV AAGHAELAWT QEAPVSSGPL LSPVPKLCRI KASKALKKKI RRFQPTALKV MTMV
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