About Protein phosphatase 1 regulatory subunit 15B
Protein phosphatase 1 regulatory subunit 15B (PPP1R15B) is a protein
from Homo sapiens identified by UniProt accession
Q5SWA1, 713 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 15B |
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| UniProt accession | Q5SWA1 |
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| Gene | PPP1R15B |
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| Organism | Homo sapiens |
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| Length | 713 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (119)
Diseases linked to this target (Open Targets).
- primary microcephaly-mild intellectual disability-young-onset diabetes syndrome · score 0.67
- lysosomal storage disease · score 0.46
- Alzheimer disease · score 0.46
- multiple sclerosis · score 0.46
- neurodegenerative disease · score 0.46
- Parkinson disease · score 0.46
- genetic disorder · score 0.19
- peak expiratory flow · score 0.09
- forced expiratory volume · score 0.08
- BMI-adjusted waist circumference · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5SWA1-F1 | alphafold | PREDICTED | 49.02 | — |
Amino-acid sequence (713 residues)
MEPGTGGSRK RLGPRAGFRF WPPFFPRRSQ AGSSKFPTPL GPENSGNPTL LSSAQPETRV SYWTKLLSQL LAPLPGLLQK VLIWSQLFGG MFPTRWLDFA GVYSALRALK GREKPAAPTA QKSLSSLQLD SSDPSVTSPL DWLEEGIHWQ YSPPDLKLEL KAKGSALDPA AQAFLLEQQL WGVELLPSSL QSRLYSNREL GSSPSGPLNI QRIDNFSVVS YLLNPSYLDC FPRLEVSYQN SDGNSEVVGF QTLTPESSCL REDHCHPQPL SAELIPASWQ GCPPLSTEGL PEIHHLRMKR LEFLQQASKG QDLPTPDQDN GYHSLEEEHS LLRMDPKHCR DNPTQFVPAA GDIPGNTQES TEEKIELLTT EVPLALEEES PSEGCPSSEI PMEKEPGEGR ISVVDYSYLE GDLPISARPA CSNKLIDYIL GGASSDLETS SDPEGEDWDE EAEDDGFDSD SSLSDSDLEQ DPEGLHLWNS FCSVDPYNPQ NFTATIQTAA RIVPEEPSDS EKDLSGKSDL ENSSQSGSLP ETPEHSSGEE DDWESSADEA ESLKLWNSFC NSDDPYNPLN FKAPFQTSGE NEKGCRDSKT PSESIVAISE CHTLLSCKVQ LLGSQESECP DSVQRDVLSG GRHTHVKRKK VTFLEEVTEY YISGDEDRKG PWEEFARDGC RFQKRIQETE DAIGYCLTFE HRERMFNRLQ GTCFKGLNVL KQC
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