PRAME family member 14 (PRAMEF14)

About PRAME family member 14

PRAME family member 14 (PRAMEF14) is a protein from Homo sapiens identified by UniProt accession Q5SWL7, 474 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	PRAME family member 14
UniProt accession	Q5SWL7
Gene	PRAMEF14
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5SWL7-F1	alphafold	PREDICTED	81.56	—

Amino-acid sequence (474 residues)

MSIQAPPRLL ELAGQSLLRD QALSISAMEE LPRVLYLPLF MEAFRRRHFQ TLTVMVQAWP FTCLPLGSLM KTLHLETLKA LLEGLHMLLT QKDRPRRWKL QVLDLRDVDE NFWARWPGAW ALSCFPETMS KRQTAEDCPR MGEHQPLKVF IDICLKEIPQ DECLRYLFQW VYQRRGLVHL CCSKLVNYLT PIKHLRKSLK IIYLNSIQQL EIRNMSWPRL IRKLRCYLKE MKNLRKLVFS RCHHSMSDNE LEGRLVTKFS SVFLRLEHLQ LLKIKLITFF SGHLEQLIRC LQNPLENLEL TYGYLLEEDM KCLSQYPSLG YLKHLNLSYV LLFRISLEPL GALLEKIAAS LETLILEGCQ IHYSQLSAIL PGLSHCSQLT TFYFGRNCMS MGALKDLLCH TSGLSKLSLE TYPAPEESLN SLVRVDWEIF ALLRAELMCT LREVRQPKRI FIGPTPCPSC GSSPSEELEL HLCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards