PRAME family member 19 (PRAMEF19)

About PRAME family member 19

PRAME family member 19 (PRAMEF19) is a protein from Homo sapiens identified by UniProt accession Q5SWL8, 479 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	PRAME family member 19
UniProt accession	Q5SWL8
Gene	PRAMEF19
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5SWL8-F1	alphafold	PREDICTED	83.51	—

Amino-acid sequence (479 residues)

MSFQAPRRLL ELAGQSLLRD QALAISVLDE LPRELFPRLF VEAFTSRCCE VLKVMVQAWP FPCLPLGSLM KTPDLEILHY VVDGIDCLLA QKVRPRRWKL QVLEMRDVDE NFWTIWSGAR PLSCSPEAMS KRQTVEDCPR TGEKQPLKVF MDVCLKEKSV DEDLSFFSGW VQHRRRSVHL CCTKVVNYSM NILNFRNILE TVYPDSIQVL EIWNMCWPCM VAEVSRYLSQ MKNLRKLFIS DGCGYLPSFE SQGQLVAEFS SVFLRLEYLQ MLYMRRIRFF EGYLDQLIRC LKSPLETLAL TYGSLDEEDL KCLPWYPSLS QLKQLNLSHG TLRFIRLEPL RALLEKVAAT LQTLFLVDCG IGDSKLRVIL PALSRCSNLT TFCFHGNDTS MDGLKDLLRH TGRLSNLSLE TYPAPRESLD NRGRVISELL TPLQAELMRI LREVREPNRI FFGPVSCPCC GMSPTEQLEF NFCLRGRPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards