Zinc finger protein 678 (ZNF678)

About Zinc finger protein 678

Zinc finger protein 678 (ZNF678) is a protein from Homo sapiens identified by UniProt accession Q5SXM1, 525 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Zinc finger protein 678
UniProt accession	Q5SXM1
Gene	ZNF678
Organism	Homo sapiens
Length	525 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

body fat distribution · score 0.37
body height · score 0.37
BMI-adjusted waist circumference · score 0.33
BMI-adjusted hip circumference · score 0.31
grip strength measurement · score 0.29
osteoarthritis, hand · score 0.29
forced expiratory volume · score 0.26
BMI-adjusted waist-hip ratio · score 0.25
waist-hip ratio · score 0.25
vital capacity · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5SXM1-F1	alphafold	PREDICTED	75.75	—

Amino-acid sequence (525 residues)

MGTISLCIGV CAFEGANTST SFYKLVYTAI LSYSIQDLLP EQDMKDLCQK VTLTRHRSWG LDNLHLVKDW RTVNEGKGQK EYCNRLTQCS STKSKIFQCI ECGRNFSWRS ILTEHKRIHT GEKPYKCEEC GKVFNRCSNL TKHKRIHTGE KPYKCDECGK VFNWWSQLTN HKKIHTGEKP YKCDECDKVF NWWSQLTSHK KIHSGEKPYP CEECGKAFTQ FSNLTQHKRI HTGEKPYKCK ECCKAFNKFS NLTQHKRIHT GEKPYKCEEC GNVFNECSHL TRHRRIHTGE KPYKCEECGK AFTQFASLTR HKRIHTGEKP YQCEECGKTF NRCSHLSSHK RIHTGEKPYK CEECGRTFTQ FSNLTQHKRI HTGEKPYKCK ECGKAFNKFS SLTQHRRIHT GVKPYKCEEC GKVFKQCSHL TSHKRIHTGE KPYKCKECGK AFYQSSILSK HKRIHTEEKP YKCEECGKAF NQFSSLTRHK RIHTGEKRYK CKECGKGFYQ SSIHSKYKRI YTGEEPDKCK KCGSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards