About DNL-type zinc finger protein
DNL-type zinc finger protein (DNLZ) is a protein
from Homo sapiens identified by UniProt accession
Q5SXM8, 178 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | DNL-type zinc finger protein |
|---|
| UniProt accession | Q5SXM8 |
|---|
| Gene | DNLZ |
|---|
| Organism | Homo sapiens |
|---|
| Length | 178 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- glucose measurement · score 0.23
- HbA1c measurement · score 0.23
- type 2 diabetes mellitus · score 0.20
- fasting blood glucose measurement · score 0.20
- vital capacity · score 0.19
- neurodegenerative disease · score 0.18
- diabetes mellitus · score 0.18
- birth weight · score 0.15
- Drugs used in diabetes use measurement · score 0.15
- myocardial infarction · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5SXM8-F1 | alphafold | PREDICTED | 67.48 | — |
Amino-acid sequence (178 residues)
MLRTALRGAP RLLSRVQPRA PCLRRLWGRG ARPEVAGRRR AWAWGWRRSS SEQGPGPAAA LGRVEAAHYQ LVYTCKVCGT RSSKRISKLA YHQGVVIVTC PGCQNHHIIA DNLGWFSDLN GKRNIEEILT ARGEQVHRVA GEGALELVLE AAGAPTSTAA PEAGEDEGPP SPGKTEPS
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