About Polynucleotide 5'-hydroxyl-kinase NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9 (NOL9) is a protein
from Homo sapiens identified by UniProt accession
Q5SY16, 702 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Polynucleotide 5'-hydroxyl-kinase NOL9 |
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| UniProt accession | Q5SY16 |
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| Gene | NOL9 |
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| Organism | Homo sapiens |
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| Length | 702 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.24
- reticulocyte count · score 0.23
- mean corpuscular hemoglobin concentration · score 0.20
- HbA1c measurement · score 0.20
- reticulocyte measurement · score 0.16
- body height · score 0.12
- mean corpuscular volume · score 0.11
- mean reticulocyte volume · score 0.06
- uncombable hair syndrome · score 0.04
- Griscelli disease type 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5SY16-F1 | alphafold | PREDICTED | 77.90 | — |
Amino-acid sequence (702 residues)
MADSGLLLKR GSCRSTWLRV RKARPQLILS RRPRRRLGSL RWCGRRRLRW RLLQAQASGV DWREGARQVS RAAAARRPNT ATPSPIPSPT PASEPESEPE LESASSCHRP LLIPPVRPVG PGRALLLLPV EQGFTFSGIC RVTCLYGQVQ VFGFTISQGQ PAQDIFSVYT HSCLSIHALH YSQPEKSKKE LKREARNLLK SHLNLDDRRW SMQNFSPQCS IVLLEHLKTA TVNFITSYPG SSYIFVQESP TPQIKPEYLA LRSVGIRREK KRKGLQLTES TLSALEELVN VSCEEVDGCP VILVCGSQDV GKSTFNRYLI NHLLNSLPCV DYLECDLGQT EFTPPGCISL LNITEPVLGP PFTHLRTPQK MVYYGKPSCK NNYENYIDIV KYVFSAYKRE SPLIVNTMGW VSDQGLLLLI DLIRLLSPSH VVQFRSDHSK YMPDLTPQYV DDMDGLYTKS KTKMRNRRFR LAAFADALEF ADEEKESPVE FTGHKLIGVY TDFAFRITPR NRESHNKILR DLSILSYLSQ LQPPMPKPLS PLHSLTPYQV PFNAVALRIT HSDVAPTHIL YAVNASWVGL CKIQDDVRGY TNGPILLAQT PICDCLGFGI CRGIDMEKRL YHILTPVPPE ELRTVNCLLV GAIAIPHCVL KCQRGIEGTV PYVTTDYNFK LPGASEKIGA REPEEAHKEK PYRRPKFCRK MK
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