About FERM and PDZ domain-containing protein 1
FERM and PDZ domain-containing protein 1 (FRMPD1) is a protein
from Homo sapiens identified by UniProt accession
Q5SYB0, 1578 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | FERM and PDZ domain-containing protein 1 |
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| UniProt accession | Q5SYB0 |
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| Gene | FRMPD1 |
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| Organism | Homo sapiens |
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| Length | 1578 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.28
- Hepatoblastoma · score 0.11
- Osteoporosis · score 0.05
- osteoporosis · score 0.05
- melorheostosis · score 0.05
- dacryocystitis-osteopoikilosis syndrome · score 0.05
- reticulocyte count · score 0.05
- 12q14 microdeletion syndrome · score 0.04
- reticulocyte measurement · score 0.04
- pyknoachondrogenesis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5SYB0-F1 | alphafold | PREDICTED | 52.47 | — |
Amino-acid sequence (1578 residues)
MEELETSLFQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPARNPTQT LIPVRHTVKI DKDTLLQDYG FHISESLPLT VVAVTAGGSA HGKLFPGDQI LQMNNEPAED LSWERAVDIL REAEDSLSIT VVRCTSGVPK SSFLTEEKRA RLKTNPVKVH FAEEVLISGH SQGNSLLCMP NVLKLYLENG QTKAFKFEAN TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE EELIQQVVER EESHDYRCLF RVCFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM KCSSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK GKDIKKAISF HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGRI FNATLMLQDR ESYIALLVGA KYGISQVINS KLNIMSTLAE FANISRVELT EESEKVSVVK VYLQDVKVLT LLLESNSAKD LACLIAGYYR LLVDPVTSIF LWPGNKQQAH RVSAEEGYES RACSDSEESS EVDCVLEPLS DRRLVKLAPC RSLIKEEQPP GNSPTPEVAR RGPSTCGASS TTDSAESEAS DSANTESRGY RTSGSSESMD ALEEDDLDTC SSSRSTFFHF GSPGLAESID SDSQEERSGI ETSGFLCLLD LAQRANPQCQ KTEFSESAAL ETFGWAPELS TVRLDPRLYE GSHADYYSLC SSVSPASYLS DSSESTASRQ GGAPPAWGQQ GWTEAQPSSM LEPLALHPPL AFEDGSSDEE YYDAADKLTP PGPPSGPRDV STAEPSATSL QNKASTSSPE NSLPCGPDGR QPSRRGGVKK YAKTLRKRRS FLQTDYTSQV SFPLVPSASL ESVDDVCYYD REPYLALGAP SPTVSSLQDM QGEPGLLETK ALGLLAPLRE TKSTNPASRV MEMEPETMET KSVIDSRVSS ISAIRFRIDP NNKENSGVVP AASSSASTPH CSNPGSSGPD TAQARPSQIL PLSQDLDGIA PKEPTIEHGD SSFSLSSGDP NPDRACLASN PGLNNVSQGD TLELQLEPHV QLEMGLESFC TNHIQETAPK YTEPLLSPRD EPRSDECGIN PGEKIASIPT KEEPQGQLSL ERDREVTNKN GTNVFQEESR KDSGDSPGDV SNNVSQTLDI SSPAGKIVTS LSLDAPVTGT EQIPPHPPRD PQGQSREPPG QGCQAQEQKL FVELDLDPDF FLGKQTVSPA VPPEGIKAEA PNHVTGQDIA PRDSPEWVCF NPEPSLPEPL PCPQEDPHLE TSNHCLLSEG KSDSSSICLS AEKSFLCFAP ESHPEVSASL RVATSLGFAG MNEMVAPRIG MDQCSCQFSY ATCFRGPQPE TEEEDRDLEA HPMAPLTSPP SAGSPVVLPW RPARAHSCTT APLSRKSHIW PEYCSRALRQ LKATPASTPE GFIQLMESLL ELQDILETSW GVGNKHPPEK CTWHFTESRS RLCMGSQKLL SSCRHVIRMD QSPEEMQGAV RDTFQHLVQL AGLCFQFTDC SRCSARHREA AGNLRDVVYT YHQFIEAAKS TCERGYHDLS VKLLARQCTA LTAAVFCLTQ KFRASTAL
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