Trem-like transcript 2 protein (TREML2)

About Trem-like transcript 2 protein

Trem-like transcript 2 protein (TREML2) is a protein from Homo sapiens identified by UniProt accession Q5T2D2, 321 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Trem-like transcript 2 protein
UniProt accession	Q5T2D2
Gene	TREML2
Organism	Homo sapiens
Length	321 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

monocyte count · score 0.43
leukocyte count · score 0.43
myeloid white cell count · score 0.38
reticulocyte count · score 0.36
blood protein measurement · score 0.35
neurodegenerative disease · score 0.31
neutrophil count · score 0.27
lymphocyte count · score 0.06
reticulocyte measurement · score 0.04
urate measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T2D2-F1	alphafold	PREDICTED	64.20	—

Amino-acid sequence (321 residues)

MAPAFLLLLL LWPQGCVSGP SADSVYTKVR LLEGETLSVQ CSYKGYKNRV EGKVWCKIRK KKCEPGFARV WVKGPRYLLQ DDAQAKVVNI TMVALKLQDS GRYWCMRNTS GILYPLMGFQ LDVSPAPQTE RNIPFTHLDN ILKSGTVTTG QAPTSGPDAP FTTGVMVFTP GLITLPRLLA STRPASKTGY SFTATSTTSQ GPRRTMGSQT VTASPSNARD SSAGPESIST KSGDLSTRSP TTGLCLTSRS LLNRLPSMPS IRHQDVYSTV LGVVLTLLVL MLIMVYGFWK KRHMASYSMC SDPSTRDPPG RPEPYVEVYL I

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards