About All trans-polyprenyl-diphosphate synthase PDSS1
All trans-polyprenyl-diphosphate synthase PDSS1 (PDSS1) is a protein
from Homo sapiens identified by UniProt accession
Q5T2R2, 415 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | All trans-polyprenyl-diphosphate synthase PDSS1 |
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| UniProt accession | Q5T2R2 |
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| Gene | PDSS1 |
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| Organism | Homo sapiens |
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| Length | 415 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (125)
Diseases linked to this target (Open Targets).
- Deafness - encephaloneuropathy - obesity - valvulopathy · score 0.77
- deafness-encephaloneuropathy-obesity-valvulopathy syndrome · score 0.68
- neurodegenerative disease · score 0.37
- genetic disorder · score 0.19
- coenzyme Q10 deficiency · score 0.17
- schizophrenia · score 0.11
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.08
- brain measurement · score 0.07
- attention deficit hyperactivity disorder · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5T2R2-F1 | alphafold | PREDICTED | 78.37 | — |
Amino-acid sequence (415 residues)
MASRWWRWRR GCSWKPAARS PGPGSPGRAG PLGPSAAAEV RAQVHRRKGL DLSQIPYINL VKHLTSACPN VCRISRFHHT TPDSKTHSGE KYTDPFKLGW RDLKGLYEDI RKELLISTSE LKEMSEYYFD GKGKAFRPII VALMARACNI HHNNSRHVQA SQRAIALIAE MIHTASLVHD DVIDDASSRR GKHTVNKIWG EKKAVLAGDL ILSAASIALA RIGNTTVISI LTQVIEDLVR GEFLQLGSKE NENERFAHYL EKTFKKTASL IANSCKAVSV LGCPDPVVHE IAYQYGKNVG IAFQLIDDVL DFTSCSDQMG KPTSADLKLG LATGPVLFAC QQFPEMNAMI MRRFSLPGDV DRARQYVLQS DGVQQTTYLA QQYCHEAIRE ISKLRPSPER DALIQLSEIV LTRDK
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