Gap junction gamma-2 protein (GJC2)

About Gap junction gamma-2 protein

Gap junction gamma-2 protein (GJC2) is a protein from Homo sapiens identified by UniProt accession Q5T442, 439 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	Gap junction gamma-2 protein
UniProt accession	Q5T442
Gene	GJC2
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

Pelizaeus-Merzbacher-like disease due to GJC2 mutation · score 0.78
Autosomal recessive spastic paraplegia type 44 · score 0.77
hypomyelinating leukodystrophy 2 · score 0.73
Milroy disease · score 0.71
hereditary spastic paraplegia 44 · score 0.68
lymphatic malformation 3 · score 0.62
Spastic paraplegia · score 0.54
genetic disorder · score 0.47
Intellectual disability · score 0.34
Abnormality of the nervous system · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T442-F1	alphafold	PREDICTED	67.05	—

Amino-acid sequence (439 residues)

MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGEAIYSDE QAKFTCNTRQ PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH RLARASEQER RRALRRRPGP RRAPRAHLPP PHAGWPEPAD LGEEEPMLGL GEEEEEEETG AAEGAGEEAE EAGAEEACTK AVGADGKAAG TPGPTGQHDG RRRIQREGLM RVYVAQLVAR AAFEVAFLVG QYLLYGFEVR PFFPCSRQPC PHVVDCFVSR PTEKTVFLLV MYVVSCLCLL LNLCEMAHLG LGSAQDAVRG RRGPPASAPA PAPRPPPCAF PAAAAGLACP PDYSLVVRAA ERARAHDQNL ANLALQALRD GAAAGDRDRD SSPCVGLPAA SRGPPRAGAP ASRTGSATSA GTVGEQGRPG THERPGAKPR AGSEKGSASS RDGKTTVWI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards