About Keratinocyte proline-rich protein
Keratinocyte proline-rich protein (KPRP) is a protein
from Homo sapiens identified by UniProt accession
Q5T749, 579 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Keratinocyte proline-rich protein |
|---|
| UniProt accession | Q5T749 |
|---|
| Gene | KPRP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 579 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (100)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.22
- psoriasis · score 0.15
- prostate carcinoma · score 0.14
- Familial prostate cancer · score 0.14
- prostate cancer · score 0.14
- Blackfan-Diamond anemia · score 0.08
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
- alpha-thalassemia-myelodysplastic syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5T749-F1 | alphafold | PREDICTED | 48.75 | — |
Amino-acid sequence (579 residues)
MCDQQQIQCR LPLQQCCVKG PSFCSSQSPF AQSQVVVQAP CEMQIVDCPA SCPVQVCQVS DQAPCQSQTT QVKCQSKTKQ VKGQAQCQSK TTQVKGQAAS QSQTSSVQSQ APCQSEVSYV QCEASQPVQT CFVECAPVCY TETCYVECPV QNYVPCPAPQ PVQMYRGRPA VCQPQGRFST QCQYQGSYSS CGPQFQSRAT CNNYTPQFQL RPSYSSCFPQ YRSRTSFSPC VPQCQTQGSY GSFTEQHRSR STSRCLPPPR RLQLFPRSCS PPRRFEPCSS SYLPLRPSEG FPNYCTPPRR SEPIYNSRCP RRPISSCSQR RGPKCRIEIS SPCCPRQVPP QRCPVEIPPI RRRSQSCGPQ PSWGASCPEL RPHVEPRPLP SFCPPRRLDQ CPESPLQRCP PPAPRPRLRP EPCISLEPRP RPLPRQLSEP CLYPEPLPAL RPTPRPVPLP RPGQCEIPEP RPCLQPCEHP EPCPRPEPIP LPAPCPSPEP CRETWRSPSP CWGPNPVPYP GDLGCHESSP HRLDTEAPYC GPSSYNQGQE SGAGCGPGDV FPERRGQDGH GDQGNAFAGV KGEAKSAYF
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