Late cornified envelope protein 1C (LCE1C)

About Late cornified envelope protein 1C

Late cornified envelope protein 1C (LCE1C) is a protein from Homo sapiens identified by UniProt accession Q5T751, 118 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Late cornified envelope protein 1C
UniProt accession	Q5T751
Gene	LCE1C
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.22
head and neck squamous cell carcinoma · score 0.18
esophageal cancer · score 0.17
gastric adenocarcinoma · score 0.16
squamous cell lung carcinoma · score 0.11
blood protein measurement · score 0.07
melorheostosis · score 0.04
sarcopenia · score 0.01
Obesity · score 0.01
Parkinson disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T751-F1	alphafold	PREDICTED	52.06	—

Amino-acid sequence (118 residues)

MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGSC GSSSGGCCSS GGGGCCLSHH RRRRSHCHRP QSSGCCSQPS GGSSCCGGGS GQHSGGCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards