Protein IFIT1 homolog B (IFIT1B)

About Protein IFIT1 homolog B

Protein IFIT1 homolog B (IFIT1B) is a protein from Homo sapiens identified by UniProt accession Q5T764, 474 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Protein IFIT1 homolog B
UniProt accession	Q5T764
Gene	IFIT1B
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

pathological myopia · score 0.11
Myopia · score 0.11
varicella, severe recurrent · score 0.06
immunodeficiency 31B · score 0.06
Chronic mucocutaneous candidosis · score 0.06
Immunodeficiency by defective expression of HLA class 2 · score 0.05
T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.04
hyper-IgM syndrome type 2 · score 0.04
isolated agammaglobulinemia · score 0.04
immunodeficiency 66 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T764-F1	alphafold	PREDICTED	93.32	—

Amino-acid sequence (474 residues)

MSEESDGKLI EDSLIQLRCH FTWKLLIEAP EIPDLENRIW EEIQFLDTKY NVGIHNLLAY VKHLKGQNEE ALVSLKKAED LIQKEHANQA DIRSLVTWGN FAWVYYHMGR LAEAQTYLDK VENTCKKFAN PSRYRMECPE VDCEEGWALA KCGGKNYERA KTCFEKALEG NPENPEFNTG YAITVYRLDK FNTASGRNKA FSLHVLKRAV RLNPDDVYIR VLLALKLQDE GQEAEGEKYI EEALTSISSQ AYVFQYAAKF YRRKGSVDKA LELLKMALET TPTSAFLHHQ MGLCYRAQMI QIKEATNWQP RGQDRETVDR LVQLAICKFE KTIMLKRTFE MAYVDLAETY AEIGHHRKAE EHFQKGLRMK IFEDQLKQEI HYHYGRFQEH HGKSQDKAIT HYLKGLKIEK MSHSREKLLN ALEKLAKRCI HQNVRVVESV SLLGLIHKLK GEVSDALLCY ERALRLAADL NPIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards