About Integrator complex subunit 11
Integrator complex subunit 11 (INTS11) is a protein
from Homo sapiens identified by UniProt accession
Q5TA45, 600 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Integrator complex subunit 11 |
|---|
| UniProt accession | Q5TA45 |
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| Gene | INTS11 |
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| Organism | Homo sapiens |
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| Length | 600 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities · score 0.68
- inflammatory bowel disease · score 0.18
- refractive error measurement · score 0.15
- ulcerative colitis · score 0.14
- myxedema · score 0.11
- pulse pressure measurement · score 0.06
- systolic blood pressure · score 0.06
- drug use measurement · score 0.06
- peak expiratory flow · score 0.05
- intraocular pressure measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TA45-F1 | alphafold | PREDICTED | 90.70 | — |
Amino-acid sequence (600 residues)
MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY ITQNGRLTDF LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN MTPDRHLGAA WIDKCRPNLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF ALGRAQELCI LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPESV LLVHGEAKKM EFLKQKIEQE LRVNCYMPAN GETVTLPTSP SIPVGISLGL LKREMAQGLL PEAKKPRLLH GTLIMKDSNF RLVSSEQALK ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSVLKD HCVQHLPDGS VTVESVLLQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS
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