Late cornified envelope protein 3A (LCE3A)

About Late cornified envelope protein 3A

Late cornified envelope protein 3A (LCE3A) is a protein from Homo sapiens identified by UniProt accession Q5TA76, 89 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Late cornified envelope protein 3A
UniProt accession	Q5TA76
Gene	LCE3A
Organism	Homo sapiens
Length	89 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.23
psoriasis · score 0.22
type 2 diabetes mellitus · score 0.14
ankylosing spondylitis · score 0.12
Crohn's disease · score 0.12
ulcerative colitis · score 0.12
sclerosing cholangitis · score 0.12
urinary bladder cancer · score 0.11
psoriasis vulgaris · score 0.11
squamous cell lung carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TA76-F1	alphafold	PREDICTED	57.15	—

Amino-acid sequence (89 residues)

MSCQQNQQQC QPPPKCPAKS PAQCLPPASS SCAPSSGGCG PSSERSCCLS HHRCRRSHRC RCQSSNSCDR GSGQQGGSSS CGHSSAGCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards