Late cornified envelope protein 3B (LCE3B)

About Late cornified envelope protein 3B

Late cornified envelope protein 3B (LCE3B) is a protein from Homo sapiens identified by UniProt accession Q5TA77, 95 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Late cornified envelope protein 3B
UniProt accession	Q5TA77
Gene	LCE3B
Organism	Homo sapiens
Length	95 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

psoriasis · score 0.19
type 2 diabetes mellitus · score 0.14
sclerosing cholangitis · score 0.12
ulcerative colitis · score 0.12
ankylosing spondylitis · score 0.12
Crohn's disease · score 0.12
psoriasis vulgaris · score 0.11
psoriatic arthritis · score 0.01
Rheumatoid arthritis · score 0.01
allergic contact dermatitis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TA77-F1	alphafold	PREDICTED	57.76	—

Amino-acid sequence (95 residues)

MSCQQNQQQC QPLPKCPSPK CPPKSSAQCL PPASSCCAPR PGCCGGPSSE GGCCLSHHRC CRSHRCRRQS SNSCDRGSGQ QDGASDCGYG SGGCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards