Late cornified envelope protein 4A (LCE4A)

About Late cornified envelope protein 4A

Late cornified envelope protein 4A (LCE4A) is a protein from Homo sapiens identified by UniProt accession Q5TA78, 99 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Late cornified envelope protein 4A
UniProt accession	Q5TA78
Gene	LCE4A
Organism	Homo sapiens
Length	99 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.22
squamous cell lung carcinoma · score 0.11
COVID-19 · score 0.04
psoriasis · score 0.04
Candidemia · score 0.01
meningeal tuberculosis · score 0.00
secondary progressive multiple sclerosis · score 0.00
retinopathy · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TA78-F1	alphafold	PREDICTED	53.09	—

Amino-acid sequence (99 residues)

MSCQQNQQQC QPPPKCPIPK YPPKCPSKCA SSCPPPISSC CGSSSGGCGC CSSEGGGCCL SHHRHHRSHC HRPKSSNCYG SGSGQQSGGS GCCSGGGCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards