Late cornified envelope protein 2C (LCE2C)

About Late cornified envelope protein 2C

Late cornified envelope protein 2C (LCE2C) is a protein from Homo sapiens identified by UniProt accession Q5TA81, 110 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Late cornified envelope protein 2C
UniProt accession	Q5TA81
Gene	LCE2C
Organism	Homo sapiens
Length	110 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.23
body fat percentage · score 0.19
head and neck squamous cell carcinoma · score 0.18
ovarian cancer · score 0.18
gastric adenocarcinoma · score 0.16
low grade glioma · score 0.11
squamous cell lung carcinoma · score 0.11
endometrial cancer · score 0.10
Down syndrome · score 0.01
obstructive sleep apnea · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TA81-F1	alphafold	PREDICTED	53.43	—

Amino-acid sequence (110 residues)

MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCPPQCPAPC FPAVSSCCGP SSGSCCGPSS GGCCSSGAGG CSLSHHRPRL FHRRRHQSPD CCESEPSGGS GCCHSSGGCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards