Late cornified envelope protein 2D (LCE2D)

About Late cornified envelope protein 2D

Late cornified envelope protein 2D (LCE2D) is a protein from Homo sapiens identified by UniProt accession Q5TA82, 110 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Late cornified envelope protein 2D
UniProt accession	Q5TA82
Gene	LCE2D
Organism	Homo sapiens
Length	110 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.22
prostate adenocarcinoma · score 0.21
head and neck squamous cell carcinoma · score 0.18
esophageal cancer · score 0.17
gastric adenocarcinoma · score 0.16
squamous cell lung carcinoma · score 0.11
endometrial cancer · score 0.10
psoriasis · score 0.04
COVID-19 · score 0.04
diabetes mellitus · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TA82-F1	alphafold	PREDICTED	53.10	—

Amino-acid sequence (110 residues)

MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCPPQCPAPC SPAVSSCCGP SSGSCCGPSS GGCCSSGGGG CCLSHHRPRL FHRRRHQSPD CCESEPSGAS GCCHSSGGCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards