Transcription factor HES-5 (HES5)

About Transcription factor HES-5

Transcription factor HES-5 (HES5) is a protein from Homo sapiens identified by UniProt accession Q5TA89, 166 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	Transcription factor HES-5
UniProt accession	Q5TA89
Gene	HES5
Organism	Homo sapiens
Length	166 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (143)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
neoplasm · score 0.09
acute lymphoblastic leukemia · score 0.08
body mass index · score 0.07
inflammatory bowel disease · score 0.06
deafness · score 0.05
FEV/FVC ratio · score 0.05
hearing loss, autosomal dominant 80 · score 0.04
pulmonary arterial hypertension · score 0.04
Abnormality of refraction · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TA89-F1	alphafold	PREDICTED	72.68	—

Amino-acid sequence (166 residues)

MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH QPNSKLEKAD ILEMAVSYLK HSKAFVAAAG PKSLHQDYSE GYSWCLQEAV QFLTLHAASD TQMKLLYHFQ RPPAAPAAPA KEPKAPGAAP PPALSAKATA AAAAAHQPAC GLWRPW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards